Evidence map›Paper›PMID 34544434›Full record

ArticleJournal of nanobiotechnology2021

Accelerated complete human skin architecture restoration after wounding by nanogenerator-driven electrostimulation.

Aiping Liu, Yin Long, Jun Li, Long Gu, Aos Karim, Xudong Wang, Angela L F Gibson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Blank Spots in the Map of Human Skin: The Challenge for Xenotransplantation.International journal of molecular sciences · 2023
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Robbing Peter to Pay Paul: Chlorhexidine gluconate demonstrates short-term efficacy and long-term cytotoxicity.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022
    Article
  13. Actin Dynamics as a Multiscale Integrator of Cellular Guidance Cues.Frontiers in cell and developmental biology · 2022
    Article
  14. The Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aiping Liu *Department of Surgery, University of Wisconsin-Madison, Madison, WI, 53792, USA.
Yin Long *Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Jun LiDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Long GuDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Aos KarimDepartment of Surgery, University of Wisconsin-Madison, Madison, WI, 53792, USA.
Xudong WangDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA. xudong@engr.wisc.edu.
Angela L F GibsonDepartment of Surgery, University of Wisconsin-Madison, Madison, WI, 53792, USA. gibson@surgery.wisc.edu.ORCID http://orcid.org/0000-0003-1181-7481

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElectrostimulation (ES) therapy for wound healing is limited in clinical use due to barriers such as cumbersome equipment and intermittent delivery of therapy.

methodsWe adapted a human skin xenograft model that can be used to directly examine the nanogenerator-driven ES (NG-ES) effects on human skin in vivo-an essential translational step toward clinical application of the NG-ES technique for wound healing.

resultsWe show that NG-ES leads to rapid wound closure with complete restoration of normal skin architecture within 7 days compared to more than 30 days in the literature. NG-ES accelerates the inflammatory phase of wound healing with more rapid resolution of neutrophils and macrophages and enhances wound bed perfusion with more robust neovascularization.

conclusionOur results support the translational evaluation and optimization of the NG-ES technology to deliver convenient, efficient wound healing therapy for use in human wounds.

Indexed as

Wound HealingAnimalsBandagesElectric StimulationElectrodesHumansKeratin-15MiceMice, NudeNanotechnologySkinSkin TransplantationKeratin-15Electrical stimulationHuman skinNanogeneratorRegenerationWound healing

Identifiers

PMID34544434
PMCPMC8454068

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.