ArticleBMC infectious diseases2021
Predictors of mortality in acute pancreatitis complicated with multidrug-resistant Klebsiella pneumoniae infection.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Determinants of Antimicrobial Resistance inInternational journal of microbiology · 2026Article
- Procalcitonin as a Predictor of Mortality in Patients With Severe Acute Pancreatitis.Gastroenterology research · 2025Article
- Molecular identification ofOpen veterinary journal · 2024Article
- Effect of the Step-Jump Approach in Infected Pancreatic Necrosis: A Propensity Score-Matched Study.Journal of inflammation research · 2024Article
- Characteristics and risk factors for infection and mortality caused byFrontiers in public health · 2024Article
- Whole-Genome Sequencing and Comparative Genomics Analysis of a Newly Emerged Multidrug-Resistant Klebsiella pneumoniae Isolate of ST967.Microbiology spectrum · 2023Article
- The impact of multi-drug resistant Pseudomonas aeruginosa infections on acute pancreatitis patients.BMC infectious diseases · 2023Article
- Clinical Characteristics, Drug Resistance, and Risk Factors for Death ofInfection and drug resistance · 2023Article
- Risk Factors for Mortality Among Critical Acute Pancreatitis Patients with Carbapenem-Resistant Organism Infections and Drug Resistance of Causative Pathogens.Infectious diseases and therapy · 2022Article
- Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients.Frontiers in cellular and infection microbiology · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMultidrug-resistant (MDR) Klebsiella pneumoniae infections, from pancreatic infections to bloodstream infections, influence the mortality of patients with acute pancreatitis (AP) on the condition of limited antibiotic choices. The aim of this study was to investigate the predictor of mortality among AP patients complicated with MDR-K. pneumoniae infections.
methodsSeventy-one AP patients who occurred MDR-K. pneumoniae infections from August 1st, 2016 to August 1st, 2020 were enrolled. MDR-K. pneumoniae was defined as the K. pneumoniae strain non-susceptible to at least one agent in three or more antimicrobial categories. MDR-K. pneumoniae isolates were confirmed by Vitek-2 system. Antibiotic susceptibility test was carried out using a micro broth dilution method. Clinical characteristics and drug-resistance rates were retrospectively reviewed, and the predictors of mortality were evaluated by univariate and multivariate analyses.
resultsThe mortality rate of AP patients complicated with MDR-K. pneumoniae infections reached 46.5% (33 of 71), and pancreas (n = 53) was the most common site of MDR-K pneumoniae strains. The drug resistance rates of MDR-K. pneumoniae were high to 11 of 12 common antibiotics (more than 50.0%) except of tigecycline (23.9%). The predictor independently associated with mortality was septic shock (hazard ratio 2.959, 95% confidence intervals 1.396 - 6.272, P = 0.005).
conclusionsMore attention should be paid for pancreatic MDR-K. pneumoniae infections among AP patients The predictor for mortality of AP patients complicated with MDR-K. pneumoniae infection is septic shock. Therefore, further clinical investigations should focus on areas against septic shock.
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