Evidence map›Paper›PMID 34544358›Full record

ArticleMolecular medicine (Cambridge, Mass.)2021

Inhibitory immune checkpoints PDCD-1 and LAG-3 hypermethylation may reduce the risk of colorectal cancer.

Yuanyuan Zhang, Lei Zhang, Hongru Sun, Ying Liu, Jing Xu, Hao Huang, Jinming Fu, Ding Zhang, Tian Tian, Yashuang Zhao and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yuanyuan ZhangDepartment of Epidemiology, Public Health College of Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
Lei ZhangDepartment of Epidemiology, Public Health College of Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
Hongru SunDepartment of Epidemiology, Public Health College of Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
Ying LiuDepartment of Epidemiology, Public Health College of Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
Jing XuDepartment of Epidemiology, Public Health College of Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
Hao HuangDepartment of Epidemiology, Public Health College of Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
Jinming FuDepartment of Epidemiology, Public Health College of Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
Ding ZhangDepartment of Epidemiology, Public Health College of Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
Tian TianDepartment of Epidemiology, Public Health College of Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China. tt992536176@163.com.ORCID 0000-0002-3686-173X
Yashuang ZhaoDepartment of Epidemiology, Public Health College of Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China. zhao_yashuang@263.net.
Guiyu WangDepartment of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Street, Nangang District, Harbin, 150001, Heilongjiang, People's Republic of China. wangguiyu_hmu@163.com.
Harbin Medical University · CN

Funding

Innovative Scientific Funding Project of Harbin Medical University 31041190060Natural Science Foundation of China 30972539Natural Science Foundation of China 81473055
6 · The paper itself

Abstract

backgroundChanges in DNA methylation of immunosuppressive checkpoints may impact express and consequently affect antigen processing and presentation by tumor cells and facilitates evasion of immunosurveillance and lead to colorectal cancer (CRC). This study is to investigate the effect of PDCD-1, LAG-3 methylation statuses in peripheral blood leukocytes on CRC risk.

methodsGSE51032 dataset from Gene Expression Omnibus comprised of 166 CRC patients and 424 normal samples was used to identify significantly differentially methylated CpG sites of the two genes. A case-control study with 390 CRC patients and 397 cancer-free controls was carried out to validate the relationship between the methylation levels of the two genes and CRC susceptibility and then estimated their interactions with environmental factors on CRC risk.

resultsIn the GSE51032 dataset, cg06291111 (PDCD-1) and cg10191002 (LAG-3) were screened as the candidate CpG sites for the following study. There were significant associations between hypermethylation of PDCD-1 and LAG-3 and lower risk of CRC (OR

conclusionsPDCD-1 and LAG-3 may potentially serve as blood-based predictive biomarkers for CRC risk.

Indexed as

DNA MethylationGene Expression Regulation, NeoplasticAdultAgedAged, 80 and overAntigens, CDBiomarkers, TumorCase-Control StudiesColorectal NeoplasmsComputational BiologyCpG IslandsDatabases, GeneticDisease SusceptibilityEpigenesis, GeneticFemaleGene Expression ProfilingAntigens, CDBiomarkers, TumorImmune Checkpoint ProteinsLag3 protein, humanLymphocyte Activation Gene 3 ProteinPDCD1 protein, humanProgrammed Cell Death 1 ReceptorColorectal cancerDNA methylationLAG-3PDCD-1Peripheral blood leukocyte

Identifiers

PMID34544358
PMCPMC8454079
OpenAlexW3199164006

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.