Evidence map›Paper›PMID 34544357›Full record

ArticleBMC bioinformatics2021

Identifying homogeneous subgroups of patients and important features: a topological machine learning approach.

Ewan Carr, Mathieu Carrière, Bertrand Michel, Frédéric Chazal, Raquel Iniesta

Abstract read
In one paragraph

Article in BMC bioinformatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ewan CarrDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Mathieu CarrièreInria Sophia-Antipolis, DataShape Team, Biot, France.
Bertrand MichelEcole Centrale de Nantes, LMJL - UMR CNRS 6629, Nantes, France.
Frédéric ChazalInria Saclay, Ile-de-France, Alan Turing Building, Palaiseau, France.
Raquel IniestaDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. raquel.iniesta@kcl.ac.uk.ORCID http://orcid.org/0000-0003-1153-5417

Funding

Brain and Behavior Research Foundation 26338
6 · The paper itself

Abstract

backgroundThis paper exploits recent developments in topological data analysis to present a pipeline for clustering based on Mapper, an algorithm that reduces complex data into a one-dimensional graph.

resultsWe present a pipeline to identify and summarise clusters based on statistically significant topological features from a point cloud using Mapper.

conclusionsKey strengths of this pipeline include the integration of prior knowledge to inform the clustering process and the selection of optimal clusters; the use of the bootstrap to restrict the search to robust topological features; the use of machine learning to inspect clusters; and the ability to incorporate mixed data types. Our pipeline can be downloaded under the GNU GPLv3 license at https://github.com/kcl-bhi/mapper-pipeline .

Indexed as

AlgorithmsMachine LearningCluster AnalysisData AnalysisHumansClusteringMachine learningTopological data analysis

Identifiers

PMID34544357
PMCPMC8451168

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.