ArticlemBio2021
Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions.
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Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
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34 citing papers in PubMed, 55 citations in OpenAlex.
- Bridging bench and bedside: translational omics ofEuropean respiratory review : an official journal of the European Respiratory Society · 2026Review
- Polymicrobial Extracellular Vesicles Reduce the Innate Immune Response of Human Cystic Fibrosis Bronchial Epithelial Cells.Journal of extracellular biology · 2026Article
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- Polymicrobial extracellular vesicles reduce the innate immune response of human cystic fibrosis bronchial epithelial cells.bioRxiv : the preprint server for biology · 2026Article
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- Nanomedicine Strategies Against Biofilm-Associated Infections: Advances, Challenges, and Translational Barriers.MicrobiologyOpen · 2026Review
- Pathogenicity and virulence ofVirulence · 2025Review
- Best Practices in the Development and Use of Experimental Models of Bacterial Pneumonia: An Official American Thoracic Society Workshop Report.American journal of respiratory cell and molecular biology · 2025Article
- UnravelingmSystems · 2025Article
- Dual RNA sequencing of a co-culture model of Pseudomonas aeruginosa and human 2D upper airway organoids.Scientific reports · 2025Article
- Bacterial interactions underpin worsening lung function in cystic fibrosis-associated infections.mBio · 2025Article
- Towards improved biofilm models.Nature reviews. Microbiology · 2025Review
- A new model of endotracheal tube biofilm identifies combinations of matrix-degrading enzymes and antimicrobials able to eradicate biofilms of pathogens that cause ventilator-associated pneumonia.Microbiology (Reading, England) · 2024Article
- Recreating chronic respiratory infectionsEuropean respiratory review : an official journal of the European Respiratory Society · 2024Review
- Mucus polymer concentration andmBio · 2024Article
- We have a community problem.Journal of bacteriology · 2024Article
- Ecological patterns and processes of temporal turnover within lung infection microbiota.Microbiome · 2024Article
- Cellular arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilms.PLoS biology · 2024Article
- Article
- Integrating airway microbiome and blood proteomics data to identify multi-omic networks associated with response to pulmonary infection.The microbe · 2023Article
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Authors and funding
38 authors at 20 institutions in 5 countries.
George A O'TooleGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0002-2861-4392
Aurélie CrabbéGhent University, Ghent, Belgium.
Rolf KümmerliUniversity of Zurichgrid.7400.3, Zurich, Switzerland.ORCID 0000-0003-4084-6679
John J LiPumaUniversity of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-4033-7794
Jennifer M BombergerUniversity of Pittsburgh, Pittburgh, Pennsylvania, USA.ORCID 0000-0003-4767-6238
Jane C DaviesImperial College Londongrid.7445.2 and Royal Brompton Hospital, London, United Kingdom.
Dominique LimoliUniversity of Iowa, Iowa City, Iowa, USA.
Vanessa V PhelanUniversity of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
James B BliskaGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0002-6047-8837
William H DePasUniversity of Pittsburgh, Pittburgh, Pennsylvania, USA.
Lars E DietrichColumbia Universitygrid.21729.3f, New York, New York, USA.ORCID 0000-0003-2049-1137
Thomas H HamptonGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0003-0543-402X
Ryan HunterUniversity of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.ORCID 0000-0003-3841-1676
Cezar M KhursigaraUniversity of Guelphgrid.34429.38, Guelph, Canada.ORCID 0000-0001-9263-7604
Alexa Price-WhelanColumbia Universitygrid.21729.3f, New York, New York, USA.
Alix AshareGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Robert A CramerGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0001-5503-5006
Joanna B GoldbergEmory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-5285-5188
Freya HarrisonUniversity of Warwickgrid.7372.1, Coventry, United Kingdom.
Deborah A HoganGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0002-6366-2971
Michael A HensonUniversity of Massachusetts and the Institute for Applied Life Sciences, Amherst, Massachusetts, USA.
Dean R MaddenGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Jared R MayersBrigham and Women's Hospital and Harvard University, Boston, Massachusetts, USA.
Carey NadellDartmouth College, Hanover, New Hampshire, USA.ORCID 0000-0003-1751-4895
Dianne NewmanCaltech, Pasadena, California, USA.ORCID 0000-0003-1647-1918
Alice PrinceColumbia Universitygrid.21729.3f, New York, New York, USA.
Damian W RivettManchester Metropolitan Universitygrid.25627.34, Manchester, United Kingdom.ORCID 0000-0002-1852-6137
Joseph D SchwartzmanGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Daniel SchultzGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Donald C SheppardMcGill Universitygrid.14709.3b, Montreal, Canada.
Alan R SmythUniversity of Nottinghamgrid.4563.4, Nottingham, United Kingdom.
Melanie A SperoUniversity of Oregon, Eugene, Oregon, USA.
Bruce A StantonGeisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Paul E TurnerYale Universitygrid.47100.32, New Haven, Connecticut, USA.
Chris van der GastManchester Metropolitan Universitygrid.25627.34, Manchester, United Kingdom.ORCID 0000-0003-1101-4048
Fiona J WhelanUniversity of Nottinghamgrid.4563.4, Nottingham, United Kingdom.
Rachel WhitakerUniversity of Illinois, Urbana-Champaign, Illinois, USA.
Katrine WhitesonUniversity of California, Irvine, California, USA.ORCID 0000-0002-5423-6014
Dartmouth College · USColumbia University · USManchester Metropolitan University · GBUniversity of Nottingham · GBUniversity of Pittsburgh · USBrigham and Women's Hospital · USCalifornia Institute of Technology · USEmory University · USGhent University Hospital · BEMcGill University · CARoyal Brompton Hospital · GBUniversity of California, Irvine · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Guelph · CAUniversity of Illinois Urbana-Champaign · USUniversity of Iowa · USUniversity of Massachusetts Amherst · USUniversity of Michigan · USUniversity of Minnesota · USUniversity of Oregon · US
Funding
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5MZhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI Li Song · 2019 to 2026
$27.2MRESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9MTranslational Research CoreP30DK117469 · NIDDK · DARTMOUTH COLLEGE · PI DEAN R MADDEN · 2018 to 2026
$13.9MIntegration of redox-balancing mechanisms in Pseudomonas aeruginosa biofilmsR01AI103369 · NIAID · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DIETRICH, LARS · 2013 to 2022
$4.1MEvolved Heterogeneity Contributes to Chronic Fungal Lung InfectionsR01AI127548 · NIAID · DARTMOUTH COLLEGE · PI HOGAN, DEBORAH A · 2017 to 2025
$3.9MRetrieval, Reprocessing, Normalization and Sharing of Gene Expression and Lung Microbiome Data Sets to Facilitate AI/ML Analysis Studies of Bacterial Lung InfectionsR01HL151385 · NHLBI · DARTMOUTH COLLEGE · PI STANTON, BRUCE A. · 2021 to 2024
$2.4MMetabolic Basis of Bacterial Community Function in the Cystic Fibrosis AirwayR01AI155424 · NIAID · DARTMOUTH COLLEGE · PI O'TOOLE, GEORGE A. · 2021 to 2025
$2.3MBacterial mucin degradation in cystic fibrosis airway disease.R01HL136919 · NHLBI · UNIVERSITY OF MINNESOTA · PI HUNTER, RYAN COULSON · 2017 to 2021
$2.1MTesting the hypothesis that microbial energetic hijacking of the CF immune response selects for specific pathogens during lung function decline- Diversity SupplementR01HL152190 · NHLBI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI NEWMAN, DIANNE K · 2020 to 2023
$2.0MCharacterizing Natural Product Mediated Microbial InteractionsR35GM128690 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PHELAN, VANESSA V · 2018 to 2022
$1.9MHigh-Throughput Screening for Dab2 Inhibitors as Stabilizers of CFTRR01DK104847 · NIDDK · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2018
$1.6MMedical Research Council MR/R001898/1NHGRI NIH HHS R25 HG011447NHLBI NIH HHS R01 HL136647NHLBI NIH HHS R01 HL136919NHLBI NIH HHS R01 HL151385NHLBI NIH HHS R01 HL152190NHLBI NIH HHS T32 HL007633NIAID NIH HHS R01 AI103369NIAID NIH HHS R01 AI127548NIAID NIH HHS R01 AI155424NIDDK NIH HHS P30 DK054759NIDDK NIH HHS P30 DK117469NIDDK NIH HHS R01 DK104847NIGMS NIH HHS P20 GM130454NIGMS NIH HHS R35 GM128690
Abstract
A recent workshop titled "Developing Models to Study Polymicrobial Infections," sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 35+ investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem. The frameworks proposed here, we believe, could be generally useful in developing new model systems for other infectious diseases. Developing and validating new approaches to study the complex polymicrobial communities in the CF airway could open windows to new therapeutics to treat these recalcitrant infections, as well as uncovering organizing principles applicable to chronic polymicrobial infections more generally.
Indexed as
Models, BiologicalAnimalsBiofilmsCoinfectionCystic FibrosisHumansMicrobial InteractionsPersistent InfectionRespiratory Systemairwaychronic infectioncystic fibrosismodelspolymicrobial
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.