Evidence map›Paper›PMID 34544264›Full record

ArticleThe Journal of urology2022

Characterization of Symptoms after Radical Prostatectomy and Their Relation to Postoperative Complications.

Matthew B Clements, Amy L Tin, Connie L Estes, Ghalib Jibara, Priyanka K Desai, Behfar Ehdaie, Karim A Touijer, Peter T Scardino, James A Eastham, Melissa J Assel and 3 more

Abstract read
In one paragraph

Article in The Journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Matthew B ClementsUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0003-1358-1441
Amy L TinDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Connie L EstesUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Ghalib JibaraUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Priyanka K DesaiDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Behfar EhdaieUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Karim A TouijerUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Peter T ScardinoUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
James A EasthamUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Melissa J AsselDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Andrew J VickersDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Brett A SimonDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Vincent P LaudoneUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
SPORE In Prostate CancerP50CA092629 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI David B. Solit · 2001 to 2026
$63.0M
UROLOGY ONCOLOGY RESEARCH TRAINING GRANTT32CA082088 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Brett Stewart Carver · 1999 to 2026
$7.1M
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA092629NCI NIH HHS T32 CA082088
6 · The paper itself

Abstract

purposeMany patients will experience symptoms in the initial days after radical prostatectomy (RP), but early patient-reported symptoms have not been well characterized. Our objective was to illustrate the pattern of symptoms experienced after RP and the relation of severe symptoms to postoperative complications. MATERIALS AND

methodsIn 2016, electronic patient-reported symptom monitoring began at our institution's ambulatory surgery center. We retrospectively reviewed patients treated with minimally invasive RP who were sent a daily questionnaire completed using a web interface until postoperative day 10. Severe symptoms automatically generate a "yellow alert," which messages the clinic, while very severe symptoms generate a "red alert," additionally prompting the patient to call. We summarized rates of moderate-to-very severe symptoms and fit local polynomial regressions. We compared rates of 30-day or 90-day complications (grade ≥2) based on the presence of alert symptoms.

resultsOf 2,266 men undergoing RP, 1,942 (86%) completed surveys. Among moderate-to-very severe symptom levels, pain (72%) and dyspnea (11%) were most common. Pain, nausea and dyspnea consistently decreased over time; fever and vomiting had a flat pattern. In patients experiencing red-alert symptoms, we observed a higher risk of 30-day complications, but rates were low and differences between groups were nonsignificant (2.9% vs 1.9%; difference 1.1%; 95% CI -1.3-3.5; p=0.3). Results were similar examining 90-day complications.

conclusionsWhile symptoms are common after RP, substantial improvements occur over the first 10 days. Severe or very severe symptoms conferred at most a small absolute increase in complication risk, which should be reassuring to patients and clinicians.

Indexed as

AgedHumansLaparoscopyMaleMiddle AgedPostoperative ComplicationsProstateProstatectomyProstatic NeoplasmsRetrospective StudiesRisk AssessmentRobotic Surgical ProceduresSeverity of Illness IndexTime Factorspatient reported outcome measurespostoperative complicationsprostatectomyquality of life

Identifiers

PMID34544264
PMCPMC9172597

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.