Evidence map›Paper›PMID 34544081›Full record

ArticleJournal of vascular research2022

Microstructural Characterization of Resistance Artery Remodelling in Diabetes Mellitus.

James S Bell, Aminat O Adio, Andrew Pitt, Lindsay Hayman, Clare E Thorn, Angela C Shore, Jacqueline L Whatmore, C Peter Winlove

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

James S BellDepartment of Physics, University of Exeter, Exeter, United Kingdom.
Aminat O AdioDiabetes and Vascular Medicine, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, United Kingdom.
Andrew PittDiabetes and Vascular Medicine, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, United Kingdom.
Lindsay HaymanDiabetes and Vascular Medicine, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, United Kingdom.
Clare E ThornDiabetes and Vascular Medicine, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, United Kingdom.
Angela C ShoreDiabetes and Vascular Medicine, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School and NIHR Exeter Clinical Research Facility, Exeter, United Kingdom.
Jacqueline L WhatmoreInstitute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.
C Peter WinloveDepartment of Physics, University of Exeter, Exeter, United Kingdom.

Funding

British Heart Foundation PG/11/17/28788Department of HealthMedical Research Council MR/S037829/1
6 · The paper itself

Abstract

introductionMicrovascular remodelling is a symptom of cardiovascular disease. Despite the mechanical environment being recognized as a major contributor to the remodelling process, it is currently only understood in a rudimentary way.

objectiveA morphological and mechanical evaluation of the resistance vasculature in health and diabetes mellitus.

methodsThe cells and extracellular matrix of human subcutaneous resistance arteries from abdominal fat biopsies were imaged using two-photon fluorescence and second harmonic generation at varying transmural pressure. The results informed a two-layer mechanical model.

resultsDiabetic resistance arteries reduced in wall area as pressure was increased. This was attributed to the presence of thick, straight collagen fibre bundles that braced the outer wall. The abnormal mechanical environment caused the internal elastic lamina and endothelial and vascular smooth muscle cell arrangements to twist.

conclusionsOur results suggest diabetic microvascular remodelling is likely to be stress-driven, comprising at least 2 stages: (1) Laying down of adventitial bracing fibres that limit outward distension, and (2) Deposition of additional collagen in the media, likely due to the significantly altered mechanical environment. This work represents a step towards elucidating the local stress environment of cells, which is crucial to build accurate models of mechanotransduction in disease.

Indexed as

Vascular RemodelingAbdominal FatAgedArterial PressureArteriesCase-Control StudiesDiabetes Mellitus, Type 2Elastic TissueFemaleFibrillar CollagensHumansMaleMechanotransduction, CellularMicroscopy, Fluorescence, MultiphotonMiddle AgedStress, MechanicalFibrillar CollagensCollagenDiabetes mellitusElastinMultiphoton microscopyRemodelling

Identifiers

PMID34544081
PMCPMC8820441

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.