ArticlePhysics in medicine and biology2021
Quantitative accuracy in total-body imaging using the uEXPLORER PET/CT scanner.
Article in Physics in medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Quantitative Accuracy Assessment of the NeuroEXPLORER for Diverse Imaging Applications: Moving Beyond Standard Evaluations.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Dynamic FDG PET/CT imaging: quantitative assessment, advantages and application in the diagnosis of malignant solid tumors.Frontiers in oncology · 2025Review
- Recent Breakthroughs in PET-CT Multimodality Imaging: Innovations and Clinical Impact.Bioengineering (Basel, Switzerland) · 2024Review
- Performance and application of the total-body PET/CT scanner: a literature review.EJNMMI research · 2024Review
- The quest for multifunctional and dedicated PET instrumentation with irregular geometries.Annals of nuclear medicine · 2024Review
- Total-Body Perfusion Imaging with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Investigating the influence of long-axial versus short-axial field of view PET/CT on stage migration in lymphoma and non-small cell lung cancer.Nuclear medicine communications · 2023Article
- Comparative studies of the sensitivities of sparse and full geometries of Total-Body PET scanners built from crystals and plastic scintillators.EJNMMI physics · 2023Article
- High-Temporal-Resolution Lung Kinetic Modeling Using Total-Body Dynamic PET with Time-Delay and Dispersion Corrections.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Will extended field-of-view PET/CT depopulate the graveyard of failed PET radiopharmaceuticals?Cancer imaging : the official publication of the International Cancer Imaging Society · 2022Review
- Efficient Delay Correction for Total-Body PET Kinetic Modeling Using Pulse Timing Methods.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Review
- Radioembolization Dosimetry with Total-BodyJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- RelatingPhysics in medicine and biology · 2022Article
- Total-body PET/CT - First Clinical Experiences and Future Perspectives.Seminars in nuclear medicine · 2022Review
- Lutetium background radiation in total-body PET-A simulation study on opportunities and challenges in PET attenuation correction.Frontiers in nuclear medicine · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Absolute quantification of regional tissue concentration of radioactivity in positron emission tomography (PET) is a critical parameter-of-interest across various clinical and research applications and is affected by a complex interplay of factors including scanner calibration, data corrections, and image reconstruction. The emergence of long axial field-of-view (FOV) PET systems widens the dynamic range accessible to PET and creates new opportunities in reducing scan time and radiation dose, delayed or low radioactivity imaging, as well as kinetic modeling of the entire human. However, these imaging regimes impose challenging conditions for accurate quantification due to constraints from image reconstruction, low count conditions, as well as large and rapidly changing radioactivity distribution across a large axial FOV. We comprehensively evaluated the quantitative accuracy of the uEXPLORER total-body scanner in conditions that encompass existing and potential imaging applications (such as dynamic imaging and ultralow-dose imaging) using a set of total-body specific phantom and human measurements. Through these evaluations we demonstrated a relative count rate accuracy of ±3%-4% using the NEMA NU 2-2018 protocol, an axial uniformity spread of ±3% across the central 90% axial FOV, and a 3% activity bias spread from 17 to 474 MBq
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Registered trials
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