ArticleCell calcium2021
Dimming the donor to brighten up FRET-based biosensors.
Article in Cell calcium, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The current biosensors based on Förster resonance energy transfer (FRET) lack good anisotrophy-based indicators for detecting rotational changes triggered by analyte-binding. Laskaratou et al. developed a FRET-induced Angular Displacement Evaluation via Dim donor (FADED) tool to expand the existing toolkit. With less bleed-through from a donor with dim fluorescence, the changes in acceptor anisotropy signals of these tools could readily indicate cytosolic calcium dynamics.
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