Observational studyAmerican journal of respiratory and critical care medicine2021
Latent Class Analysis Reveals COVID-19-related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids.
Registry-linked trialAbstract readObservational Study
In one paragraph
Observational study in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07511582 (Efficacy, Safety, and Tolerability of Methylprednisolone in Critically Ill Patients With the Hyperinflammatory Phenotype), which is not on this map. Cited by 172 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy, Safety, and Tolerability of Methylprednisolone in Critically Ill Patients With the Hyperinflammatory Phenotype: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Trial
Who cites it
172 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A consensus immune dysregulation framework for sepsis and critical illnesses.Nature medicine · 2025Guideline
- Evolving outcomes of extracorporeal membrane oxygenation during the first 2 years of the COVID-19 pandemic: a systematic review and meta-analysis.Critical care (London, England) · 2022Pooled it
- Early differential protein expression in blood and bronchoalveolar fluid among ARDS phenotypes.Scientific reports · 2026Trial
- Predicting mortality with machine learning & biomarkers: A cohort analysis from aerosolized β₂-agonist for treatment of acute lung injury (ALTA) trial.Physiological reports · 2026Trial
- Treatment with Allogeneic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multicenter Phase 2b Clinical Trial (STAT).American journal of respiratory and critical care medicine · 2026Trial
- Safety and efficacy of inhaled PEG-ADM in ARDS patients: a randomised controlled trial.Critical care (London, England) · 2025Trial
- Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome.The Journal of clinical investigation · 2024Trial
- Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial.Critical care (London, England) · 2024Trial
- Simvastatin in Critically Ill Patients with Covid-19.The New England journal of medicine · 2023Trial
- Inflammatory subphenotypes in patients at risk of ARDS: evidence from the LIPS-A trial.Intensive care medicine · 2023Trial
- Plasma matrix metalloproteinase-3 predicts mortality in acute respiratory distress syndrome: a biomarker analysis of a randomized controlled trial.Respiratory research · 2023Trial
- Efficacy and safety of intravenous imatinib in COVID-19 ARDS: a randomized, double-blind, placebo-controlled clinical trial.Critical care (London, England) · 2023Trial
- Immunomodulation and endothelial barrier protection mediate the association between oral imatinib and mortality in hospitalised COVID-19 patients.The European respiratory journal · 2022Trial
- A randomized, double-blind, placebo-controlled trial of intravenous alpha-1 antitrypsin for ARDS secondary to COVID-19.Med (New York, N.Y.) · 2022Trial
- Early, biomarker-guided steroid dosing in COVID-19 Pneumonia: a pilot randomized controlled trial.Critical care (London, England) · 2022Trial
- Lung-Cardiovascular Interactions and Derangements in ARDS.Comprehensive physiology · 2026Review
- Protein Quantification Platforms For Use In Critical Care Precision Medicine Trials: A Scoping Review.Critical care explorations · 2026Article
- Contrast-enhanced ultrasound-based energy response phenotyping in thyroid nodule ablation: identifying heterogeneous subgroups via latent class analysis.Quantitative imaging in medicine and surgery · 2026Article
- Identification of Heterogenous Treatment Response to Corticosteroids Among Patients With Ventilator-Dependent Respiratory Failure: An Observational Cohort Study.CHEST critical care · 2026Article
- Inflammation, Endothelial Dysfunction, and Frailty Over 3 Years in Survivors of COVID-19 ARDS vs Pneumonia.CHEST critical care · 2026Article
112 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
25 authors.
Pratik SinhaDepartment of Anesthesiology, Washington University Medical School, Saint Louis, Missouri.
David FurfaroDivision of Pulmonary, Allergy, and Critical Care Medicine.
Matthew J CummingsDivision of Pulmonary, Allergy, and Critical Care Medicine.
Darryl AbramsDivision of Pulmonary, Allergy, and Critical Care Medicine.ORCID 0000-0001-9073-3897
Kevin DelucchiDepartment of Psychiatry & Behavioral Sciences.
Manoj V MaddaliDepartment of Medicine.
June HeDepartment of Anesthesiology, Washington University Medical School, Saint Louis, Missouri.
Alison ThompsonDivision of Pulmonary, Allergy, and Critical Care Medicine.
Michael MurnDivision of Pulmonary, Allergy, and Critical Care Medicine.
John FountainDepartment of Internal Medicine, and.
Amanda RosenDepartment of Internal Medicine, and.
Shelief Y Robbins-JuarezVagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Matthew A AdanVagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Tejus SatishVagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Mahesh MadhavanDivision of Cardiology, Department of Medicine.
Aakriti GuptaDivision of Cardiology, Department of Medicine.
Alexander K LyashchenkoDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and NewYork-Presbyterian Hospital, New York, New York.
Cara AgerstrandDivision of Pulmonary, Allergy, and Critical Care Medicine.
Natalie H YipDivision of Pulmonary, Allergy, and Critical Care Medicine.
Kristin M BurkartDivision of Pulmonary, Allergy, and Critical Care Medicine.
Jeremy R BeitlerDivision of Pulmonary, Allergy, and Critical Care Medicine.ORCID 0000-0003-0797-2374
Matthew R BaldwinDivision of Pulmonary, Allergy, and Critical Care Medicine.
Carolyn S CalfeeDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine.
Daniel BrodieDivision of Pulmonary, Allergy, and Critical Care Medicine.
Max R O'DonnellDivision of Pulmonary, Allergy, and Critical Care Medicine.
Funding
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0MPrecision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8MPrecision Medicine in Sepsis with Critical IllnessR35GM142992 · NIGMS · WASHINGTON UNIVERSITY · PI Pratik Sinha · 2021 to 2026
$2.4MCAPRI: Columbia Cancer Training Program for Resident-InvestigatorsR38CA231577 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CREW, KATHERINE D, SCHWARTZ, GARY K · 2018 to 2021
$1.4MBreath stacking dyssynchrony in acute respiratory distress syndromeK23HL133489 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BEITLER, JEREMY R. · 2017 to 2021
$871kMeasuring lung stress to identify occult ventilation-induced lung injury in ARDSR21HL145506 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BEITLER, JEREMY R. · 2019 to 2020
$243kPhenotyping sepsis in Uganda using molecular pathogen diagnostics and latent class modelingF32AI147528 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CUMMINGS, MATTHEW JOHN · 2019 to 2020
$177kNCATS NIH HHS UL1 TR001873NCI NIH HHS R38 CA231577NHLBI NIH HHS K23 HL133489NHLBI NIH HHS R21 HL145506NHLBI NIH HHS R35 HL140026NIAID NIH HHS F32 AI147528NIGMS NIH HHS R35 GM142992
Abstract
PubMed holds no abstract for this paper.
Indexed as
COVID-19 Drug TreatmentLatent Class AnalysisAdrenal Cortex HormonesAgedCohort StudiesCOVID-19FemaleHumansMaleMiddle AgedRespiratory Distress SyndromeRetrospective StudiesAdrenal Cortex HormonesARDSCOVID-19latent class analysisphenotyping
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT07511582ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.