Evidence map›Paper›PMID 34543425›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2022

Serum Vitamin D: Correlates of Baseline Concentration and Response to Supplementation in VITAL-DKD.

Cora M Best, Leila R Zelnick, Kenneth E Thummel, Simon Hsu, Christine Limonte, Ravi Thadhani, Howard D Sesso, JoAnn E Manson, Julie E Buring, Samia Mora and 6 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Cora M BestDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8400-9288
Leila R ZelnickKidney Research Institute, University of Washington, Seattle, WA, USA.
Kenneth E ThummelDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Simon HsuKidney Research Institute, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3780-294X
Christine LimonteKidney Research Institute, University of Washington, Seattle, WA, USA.
Ravi ThadhaniMass General Brigham, Harvard Medical School, Boston, MA, USA.
Howard D SessoDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Julie E BuringDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Samia MoraDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6283-0980
I-Min LeeDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nancy R CookDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Georgina FriedenbergDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Heike Luttmann-GibsonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ian H de BoerKidney Research Institute, University of Washington, Seattle, WA, USA.
Andrew N HoofnagleDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6449-0243
Brigham and Women's Hospital · USUniversity of Washington · USHarvard University · US

Funding

PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4M
VITamin D and omegA-3 triaL (VITAL)U01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2009 to 2014
$23.6M
The VITamin D and OmegA-3 TriaL (VITAL)R01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2015 to 2019
$20.9M
Nutrition, Obesity and Atherosclerosis Training ProgramT32HL007028 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1985 to 2026
$6.4M
The VITamin D and OmegA-3 TriaL (VITAL): Post-Intervention Follow-UpR01AT011729 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI Jun Li, JoAnn Elisabeth Manson · 2021 to 2026
$5.2M
Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney diseaseR01DK088762 · NIDDK · UNIVERSITY OF WASHINGTON · PI DE BOER, IAN H · 2010 to 2019
$4.7M
Patient Centered Approaches to Preventing ASCVD EventsK24HL136852 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAMIA MORA · 2018 to 2026
$1.1M
Common Genetic Variation of Vitamin D Binding Protein and Vitamin D KineticsF32DK128864 · NIDDK · UNIVERSITY OF WASHINGTON · PI BEST, CORA M · 2021 to 2021
$63k
NCCIH NIH HHS R01 AT011729NCI NIH HHS R01 CA138962NCI NIH HHS U01 CA138962NHLBI NIH HHS K24 HL136852NHLBI NIH HHS T32 HL007028NIDDK NIH HHS F32 DK128864NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK088762NIDDK NIH HHS R01DK088762-S1NIH HHS T32HL007028NIH HHS U01CA138962
6 · The paper itself

Abstract

contextThe effect of daily vitamin D supplementation on the serum concentration of vitamin D (the parent compound) may offer insight into vitamin D disposition.

objectiveTo assess the total serum vitamin D response to vitamin D3 supplementation and whether it varies according to participant characteristics. To compare results with corresponding results for total serum 25-hydroxyvitamin D [25(OH)D], which is used clinically and measured in supplementation trials.

designExploratory study within a randomized trial.

intervention2000 International Units of vitamin D3 per day (or matching placebo).

settingCommunity-based.

participants161 adults (mean ± SD age 70 ± 6 years; 66% males) with type 2 diabetes.

main outcome measuresChanges in total serum vitamin D and total serum 25(OH)D concentrations from baseline to year 2.

resultsAt baseline, there was a positive, nonlinear relation between total serum vitamin D and total serum 25(OH)D concentrations. Adjusted effects of supplementation were a 29.2 (95% CI: 24.3, 34.1) nmol/L increase in serum vitamin D and a 33.4 (95% CI: 27.7, 39.2) nmol/L increase in serum 25(OH)D. Among those with baseline 25(OH)D < 50 compared with ≥ 50 nmol/L, the serum vitamin D response to supplementation was attenuated (15.7 vs 31.2 nmol/L; interaction P-value = 0.02), whereas the serum 25(OH)D response was augmented (47.9 vs 30.7 nmol/L; interaction P-value = 0.05).

conclusionsVitamin D3 supplementation increases total serum vitamin D and 25(OH)D concentrations with variation according to baseline 25(OH)D, which suggests that 25-hydroxylation of vitamin D3 is more efficient when serum 25(OH)D concentration is low.

Indexed as

Dietary SupplementsAgedCholecalciferolDiabetes Mellitus, Type 2Diabetic NephropathiesFatty Acids, Omega-3FemaleHumansMaleMiddle AgedTreatment OutcomeVitamin DVitamin D Deficiency25-hydroxyvitamin DCholecalciferolFatty Acids, Omega-3Vitamin D25-hydroxyvitamin Dbiomarkerscholecalciferolliquid chromatography-tandem mass spectrometryvitamin D

Identifiers

PMID34543425
PMCPMC8764322
OpenAlexW3200563707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.