ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
The Association Between Epigenetic Clocks and Physical Functioning in Older Women: A 3-Year Follow-up.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- DNA methylation signatures in skeletal muscle associated with physical function in healthy older adults.GeroScience · 2026Article
- Association of muscle mass and strength with blood-based epigenetic aging among middle-aged and older adults in the United States.GeroScience · 2026Article
- Associations of epigenetic age acceleration with motor impairment: Evidence from the Parkinson's Progression Markers Initiative cohort.Neurobiology of aging · 2026Article
- Biological age-acceleration in relation to muscle mass, strength and function: findings from the Hertfordshire Cohort Study.Aging clinical and experimental research · 2026Article
- Associations of weekly working hours with biological aging and all-cause and cardiovascular mortality: the role of lifestyle.Journal of occupational medicine and toxicology (London, England) · 2026Article
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- Heterogeneous trajectories of appendicular skeletal muscle mass change and cognitive impairment in community-dwelling middle-aged and older adults.Scientific reports · 2026Article
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- Article
- Associations of Epigenetic Age Acceleration with Motor Impairment: Evidence from the PPMI Cohort.medRxiv : the preprint server for health sciences · 2025Article
- Biological Ageing Acceleration and Functional Capacities Across the Lifespan in the INSPIRE-T Cohort.Journal of cachexia, sarcopenia and muscle · 2025Article
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future.Aging and disease · 2024Review
- High-Impact Pain Is Associated With Epigenetic Aging Among Middle-Aged and Older Adults: Findings From the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Epigenetic Aging and Musculoskeletal Outcomes in a Cohort of Women Living With HIV.The Journal of infectious diseases · 2024Article
- Metabolic syndrome and epigenetic aging: a twin study.International journal of obesity (2005) · 2024Article
- Measuring healthy ageing: current and future tools.Biogerontology · 2023Review
- Mortality Associations With DNA Methylation-Based Biological Aging and Physical Functioning Measures Across a 20-Year Follow-up Period.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Drugs, clocks and exercise in ageing: hype and hope, fact and fiction.The Journal of physiology · 2023Review
- Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain.Frontiers in aging neuroscience · 2023Article
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8 authors.
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Abstract
backgroundEpigenetic clocks are composite markers developed to predict chronological age or mortality risk from DNA methylation (DNAm) data. The present study investigated the associations between 4 epigenetic clocks (Horvath's and Hannum's DNAmAge and DNAm GrimAge and PhenoAge) and physical functioning during a 3-year follow-up.
methodWe studied 63- to 76-year-old women (N = 413) from the Finnish Twin Study on Aging. DNAm was measured from blood samples at baseline. Age acceleration (AgeAccel), that is, discrepancy between chronological age and DNAm age, was determined as residuals from linear model. Physical functioning was assessed under standardized laboratory conditions at baseline and at follow-up. A cross-sectional analysis was performed with path models, and a longitudinal analysis was conducted with repeated measures linear models. A nonrandom missing data analysis was performed.
resultsIn comparison to the other clocks, GrimAgeAccel was more strongly associated with physical functioning. At baseline, GrimAgeAccel was associated with lower performance in the Timed Up and Go (TUG) test and the 6-minute walk test. At follow-up, significant associations were observed between GrimAgeAccel and lowered performance in the TUG, 6-minute and 10-m walk tests, and knee extension and ankle plantar flexion strength tests.
conclusionsThe DNAm GrimAge, a novel estimate of biological aging, associated with decline in physical functioning over the 3-year follow-up in older women. However, associations between chronological age and physical function phenotypes followed similar pattern. Current epigenetic clocks do not provide strong benefits in predicting the decline of physical functioning at least during a rather short follow-up period and restricted age range.
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