SynthesisPLoS neglected tropical diseases2021
Measuring endemicity and burden of leprosy across countries and regions: A systematic review and Delphi survey.
Synthesis in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Experiences of living with leprosy: A systematic review and qualitative evidence synthesis.PLoS neglected tropical diseases · 2022Pooled it
- Temporal and spatial patterns of Leprosy in Uganda, 2020-2024: A nationwide surveillance analysis.PLoS neglected tropical diseases · 2026Article
- The development of a performance evaluation index system for internet hospitals in Qingdao, China: A Delphi consensus study.SAGE open medicine · 2026Article
- Endemicity, disability and neglect: Leprosy in Colombia 2007-2020.PLoS neglected tropical diseases · 2025Article
- Ecuador Towards Zero Leprosy: A Twenty-Three-Year Retrospective Epidemiologic and Spatiotemporal Analysis of Leprosy in Ecuador.Tropical medicine and infectious disease · 2024Article
- Skin diseases among the tribal population of Kerala: the challenges and way forward.International journal for equity in health · 2024Article
- Exploring Active Case Detection Approaches for Leprosy Diagnosis in Varied Endemic Settings: A Comprehensive Scoping Review.Life (Basel, Switzerland) · 2024Article
- The International Classification of Functioning, Disability and Health to map leprosy-related disability in rural and remote areas in Indonesia.PLoS neglected tropical diseases · 2024Article
- Interventions to reduce leprosy related stigma: A systematic review.PLOS global public health · 2024Article
- Leprosy: treatment, prevention, immune response and gene function.Frontiers in immunology · 2024Review
- New cases of childhood leprosy in two male siblings in low endemic province: an iceberg phenomenon?Dermatology reports · 2023Article
- A Comparison of Cathelicidin Levels in the Skin of Leprosy Patients and Their Household Contacts.Acta medica academica · 2023Observational
- Measuring leprosy case detection delay and associated factors in Indonesia: a community-based study.BMC infectious diseases · 2023Article
- Field-friendly anti-PGL-I serosurvey in children to monitorFrontiers in medicine · 2023Article
- Pathogenicity and virulence ofVirulence · 2022Review
- A Young Female With Borderline Lepromatous Leprosy and Tuberculous Lymphadenitis: A Rare Coinfection.Cureus · 2022Article
- Epidemiological characteristics of leprosy during the period 2005-2020: A retrospective study based on the Chinese surveillance system.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeprosy is a chronic infectious disease caused by Mycobacterium leprae, the annual new case detection in 2019 was 202,189 globally. Measuring endemicity levels and burden in leprosy lacks a uniform approach. As a result, the assessment of leprosy endemicity or burden are not comparable over time and across countries and regions. This can make program planning and evaluation difficult. This study aims to identify relevant metrics and methods for measuring and classifying leprosy endemicity and burden at (sub)national level.
methodsWe used a mixed-method approach combining findings from a systematic literature review and a Delphi survey. The literature search was conducted in seven databases, searching for endemicity, burden and leprosy. We reviewed the available evidence on the usage of indicators, classification levels, and scoring methods to measure and classify endemicity and burden. A two round Delphi survey was conducted to ask experts to rank and weigh indicators, classification levels, and scoring methods.
resultsThe literature review showed variation of indicators, levels, and cut-off values to measure leprosy endemicity and/or burden. The most used indicators for endemicity include new case detection rate (NCDR), new cases among children and new cases with grade 2 disability. For burden these include NCDR, MB cases, and prevalence. The classification levels 'high' and 'low' were most important. It was considered most relevant to use separate scoring methods for endemicity and burden. The scores would be derived by use of multiple indicators.
conclusionThere is great variation in the existing method for measuring endemicity and burden across countries and regions. Our findings contribute to establishing a standardized uniform approach to measure and classify leprosy endemicity and burden at (sub)national level, which would allow effective communication and planning of intervention strategies.
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