Evidence map›Paper›PMID 34543121›Full record

ArticleInfection and immunity2021

Bile Salts Promote ToxR Regulon Activation during Growth under Virulence-Inducing Conditions.

Thomas F Bina, Dillon E Kunkle, X Renee Bina, Steven J Mullett, Stacy G Wendell, James E Bina

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. DNA repair is essential forJournal of bacteriology · 2025
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  7. DNA repair is essential forbioRxiv : the preprint server for biology · 2025
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  8. eLife · 2023
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Thomas F Bina *University of Pittsburgh School of Medicinegrid.471408.e, Department of Microbiology and Molecular Genetics, Pittsburgh, Pennsylvania, USA.
Dillon E Kunkle *University of Pittsburgh School of Medicinegrid.471408.e, Department of Microbiology and Molecular Genetics, Pittsburgh, Pennsylvania, USA.
X Renee BinaUniversity of Pittsburgh School of Medicinegrid.471408.e, Department of Microbiology and Molecular Genetics, Pittsburgh, Pennsylvania, USA.
Steven J MullettUniversity of Pittsburgh School of Medicinegrid.471408.e, Department of Pharmacology and Chemical Biology, the Health Sciences Metabolomics and Lipidomics Core, Pittsburgh, Pennsylvania, USA.
Stacy G WendellUniversity of Pittsburgh School of Medicinegrid.471408.e, Department of Pharmacology and Chemical Biology, the Health Sciences Metabolomics and Lipidomics Core, Pittsburgh, Pennsylvania, USA.
James E BinaUniversity of Pittsburgh School of Medicinegrid.471408.e, Department of Microbiology and Molecular Genetics, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8905-2055
University of Pittsburgh · US

Funding

Viral Persistence and PathogenesisT32AI049820 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELUCA, NEAL A. · 2001 to 2024
$5.5M
Environmental adaptation by Vibrio choleraeR01AI132460 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JAMES Edward BINA · 2018 to 2026
$3.2M
Bringing Untargeted Metabolomics to PittS10OD023402 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GELHAUS, STACY LYNN · 2018 to 2018
$594k
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (DIR, NIAID) R01AI132460Division of Intramural Research, National Institute of Allergy and Infectious Diseases (DIR, NIAID) T32AI049820HHS | NIH | National Institute of General Medical Sciences (NIGMS) S10OD023402NIAID NIH HHS R01 AI132460NIAID NIH HHS T32 AI049820NIH HHS S10 OD023402
6 · The paper itself

Abstract

Cholera is an epidemic disease caused by the Gram-negative bacterium Vibrio cholerae. V. cholerae is found in aquatic ecosystems and infects people through the consumption of V. cholerae-contaminated food or water. Following ingestion, V. cholerae responds to host cues to activate the expression of critical virulence genes that are under the control of a hierarchical regulatory system called the ToxR regulon. The ToxR regulon is tightly regulated and is expressed

Indexed as

Gene Expression Regulation, BacterialHost-Pathogen InteractionsRegulonBacterial ProteinsBile Acids and SaltsCholeraChromatography, LiquidDNA-Binding ProteinsHumansMass SpectrometryTranscription FactorsVibrio choleraeVirulenceVirulence FactorsBacterial ProteinsBile Acids and SaltsDNA-Binding ProteinstoxR protein, Vibrio choleraeTranscription FactorsVirulence Factorsbilebile saltscholeraTcpPToxRvirulencevirulence regulation

Identifiers

PMID34543121
PMCPMC8594600
OpenAlexW3199876837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.