Evidence map›Paper›PMID 34543116›Full record

ArticleMolecular and cellular biology2021

The ASCIZ-DYNLL1 Axis Is Essential for TLR4-Mediated Antibody Responses and NF-κB Pathway Activation.

Rui Liu, Ashleigh King, David Tarlinton, Jörg Heierhorst

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Rui LiuSt. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.
Ashleigh KingSt. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.
David TarlintonDepartment of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia.
Jörg HeierhorstSt. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.ORCID 0000-0003-2789-9514
St Vincents Institute of Medical Research · AUMonash University · AUThe University of Melbourne · AU

Funding

Worldwide Cancer Research 16-0156
6 · The paper itself

Abstract

Toll-like receptors (TLRs) and interleukin-1 (IL-1) receptors regulate immune and inflammatory responses by activating the NF-κB pathway. Here, we report that B-cell-specific loss of dynein light chain 1 (DYNLL1, LC8) or its designated transcription factor ASCIZ (ATMIN) leads to severely reduced

Indexed as

AnimalsAntibody FormationB-LymphocytesCD40 AntigensCells, CulturedCytoplasmic DyneinsImmunoglobulin Class SwitchingMiceMice, Inbred C57BLNF-kappa BNF-KappaB Inhibitor alphaT-LymphocytesToll-Like Receptor 4Transcription FactorsTumor Necrosis Factor-alphaTumor Suppressor p53-Binding Protein 1ATMIN protein, mouseCD40 AntigensCytoplasmic DyneinsDYNLL1 protein, mouseNF-kappa BNF-KappaB Inhibitor alphaTlr4 protein, mouseTnf protein, mouseToll-Like Receptor 4Transcription FactorsTrp53bp1 protein, mouseTumor Necrosis Factor-alphaTumor Suppressor p53-Binding Protein 1B-cell responsesBIMcell proliferationDYNLL1immunizationNF-κB

Identifiers

PMID34543116
PMCPMC8608018
OpenAlexW3199253178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.