Evidence map›Paper›PMID 34543090›Full record

ArticleAntimicrobial agents and chemotherapy2021

The QcrB Inhibitors TB47 and Telacebec Do Not Potentiate the Activity of Clofazimine in Mycobacterium abscessus.

Ria Sorayah, Garret C Moraski, Daniel Barkan, Kevin Pethe

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Assessment of TB47 as a potential novel therapeutic agent:Antimicrobial agents and chemotherapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Ria SorayahNTU Institute for Health Technologies, Interdisciplinary Graduate Program, Nanyang Technological Universitygrid.59025.3b, Singapore.
Garret C MoraskiDepartment of Chemistry and Biochemistry, Montana State Universitygrid.41891.35, Bozeman, Montana, USA.
Daniel BarkanKoret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.ORCID 0000-0002-5691-1757
Kevin PetheLee Kong Chian School of Medicine, Nanyang Technological Universitygrid.59025.3b, Singapore.ORCID 0000-0003-0916-8873
Nanyang Technological University · SGHebrew University of Jerusalem · ILMontana State University · US

Funding

National Research Foundation Singapore (NRF) NRF-NRFI06-2020-0004
6 · The paper itself

Abstract

The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus

Indexed as

Mycobacterium abscessusMycobacterium Infections, NontuberculousAnti-Bacterial AgentsAntitubercular AgentsClofazimineHumansImidazolesMicrobial Sensitivity TestsPiperidinesPyridinesAnti-Bacterial AgentsAntitubercular AgentsClofazimineImidazolesPiperidinesPyridinestelacebeccytochrome bcc:aa3nontuberculous mycobacteriaoxidative phosphorylationQ203terminal oxidasetuberculosis

Identifiers

PMID34543090
PMCPMC8597762
OpenAlexW3200049827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.