Evidence map›Paper›PMID 34543077›Full record

ArticleAIDS care2022

Key influences on the decision to initiate PrEP among adolescent girls and young women within routine maternal child health and family planning clinics in Western Kenya.

Zoe Rogers, Jillian Pintye, John Kinuthia, Gabrielle O'Malley, Felix Abuna, Jaclyn Escudero, Melissa Mugambi, Mercy Awuor, Annabell Dollah, Julia C Dettinger and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in AIDS care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03070600 (Delivering PrEP in Pregnancy), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03070600 phase4completednot on this map

Delivering PrEP in Pregnancy

TypeinterventionalSponsorUniversity of WashingtonRan2018 to 2021Enrolled4,447ConditionsHIV Infections, Pregnancy RelatedArmsUniversal PrEP Counseling, Targeted PrEP Counseling
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zoe RogersDepartment of Global Health, University of Washington, Seattle, WA, USA.
Jillian PintyeDepartment of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, WA, USA.
John KinuthiaDepartment of Global Health, University of Washington, Seattle, WA, USA.
Gabrielle O'MalleyDepartment of Global Health, University of Washington, Seattle, WA, USA.
Felix AbunaKenyatta National Hospital, Nairobi, Kenya.
Jaclyn EscuderoDepartment of Global Health, University of Washington, Seattle, WA, USA.
Melissa MugambiDepartment of Global Health, University of Washington, Seattle, WA, USA.
Mercy AwuorKenyatta National Hospital, Nairobi, Kenya.
Annabell DollahKenyatta National Hospital, Nairobi, Kenya.
Julia C DettingerDepartment of Global Health, University of Washington, Seattle, WA, USA.
Pamela KohlerDepartment of Global Health, University of Washington, Seattle, WA, USA.
Grace John-StewartDepartment of Global Health, University of Washington, Seattle, WA, USA.
Kristin Beima-SofieDepartment of Global Health, University of Washington, Seattle, WA, USA.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Delivering PrEP in PregnancyR01AI125498 · NIAID · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2016 to 2020
$3.6M
Evaluating Infant PrEP Exposure During Pregnancy and BreastfeedingR01HD100201 · NICHD · UNIVERSITY OF WASHINGTON · PI PINTYE, JILLIAN · 2019 to 2023
$3.4M
PrEP optimized for mothers (PrOM): efficient PrEP integration in MCH clinicsR01HD094630 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C., KOHLER, PAMELA · 2017 to 2021
$3.3M
mWACh-PrEP: A SMS-based Support Intervention to Enhance PrEP Adherence during Pregnancy and BreastfeedingR01NR019220 · NINR · UNIVERSITY OF WASHINGTON · PI KINUTHIA, JOHN, PINTYE, JILLIAN · 2020 to 2024
$2.9M
NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI125498NICHD NIH HHS R01 HD094630NICHD NIH HHS R01 HD100201NINR NIH HHS R01 NR019220
6 · The paper itself

Abstract

We sought to understand influences on PrEP uptake among Kenyan adolescent girls and young women (AGYW) whose decision on PrEP use was misaligned with their risk for HIV acquisition. In-depth interviews were conducted with 47 Kenyan HIV-negative AGYW aged 15-24 years who were offered PrEP during routine maternal and child health and family planning services. AGYW were sampled from two groups (1) declined PrEP and had ≥1 sexual partner(s) of unknown HIV status and (2) initiated PrEP and reported having one HIV-negative partner. AGYW with HIV-negative partners initiated PrEP due to known or suspected infidelity. AGYW with partners of unknown HIV status recognized PrEP as a helpful HIV prevention tool, yet worried about partner reactions and prioritized avoiding uncomfortable or unsafe situations over PrEP. Among pregnant AGYW, the responsibility of motherhood and providing a future for one's family, through staying healthy and remaining HIV-free, was a strong PrEP use motivator. Among AGYW who desired future motherhood, fears that PrEP could negatively impact fertility or reduce contraceptive effectiveness led to declining PrEP. Peers positively influenced PrEP decision-making, especially personally knowing a PrEP user. Strategies are needed to enhance messaging and delivery approaches that are tailored to AGYW, including peer-led strategies.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisAdolescentAdultChildChild HealthFamily Planning ServicesFemaleHumansKenyaPregnancyYoung AdultAnti-HIV AgentsadolescentsAfricaHIV preventionPre-exposure prophylaxisPrEPwomen

Identifiers

PMID34543077
PMCPMC8934309

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.