Evidence map›Paper›PMID 34542825›Full record

ArticleCell stress & chaperones2021

HSP70i

Dinesh Jaishankar, Cormac Cosgrove, Prathyaya Ramesh, James Mahon, Rohan Shivde, Emilia R Dellacecca, Shiayin F Yang, Jeffrey Mosenson, José A Guevara-Patiño, I Caroline Le Poole

Open access · greenAbstract read
In one paragraph

Article in Cell stress & chaperones, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Dinesh JaishankarDepartment of Dermatology & Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA. jaishank@musc.edu.
Cormac CosgroveDepartment of Dermatology & Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
Prathyaya RameshDepartment of Dermatology & Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9776-598X
James MahonCardinal Bernardin Cancer Center, Loyola University Chicago, Chicago, IL, USA.
Rohan ShivdeDepartment of Dermatology & Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
Emilia R DellaceccaDepartment of Dermatology & Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
Shiayin F YangDepartment of Otolaryngology - Head and Neck Surgery, Loyola University Medical Center, Maywood, IL, USA.
Jeffrey MosensonCardinal Bernardin Cancer Center, Loyola University Chicago, Chicago, IL, USA.
José A Guevara-PatiñoDepartment of Surgery, Loyola University Medical Center, Maywood, IL, USA.
I Caroline Le PooleDepartment of Dermatology & Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA. caroline.lepoole@northwestern.edu.
Northwestern University · USLoyola University Chicago · USLoyola University Medical Center · US

Funding

Northwestern University Skin Disease Research Center Resource-based CenterP30AR075049 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Amy S Paller · 2019 to 2026
$6.6M
Separating autoimmunity and anti-tumor immunityR01CA191317 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LE POOLE, I. CAROLINE · 2015 to 2019
$1.8M
NCI NIH HHS R01 CA191317NIAMS NIH HHS P30 AR075049
6 · The paper itself

Abstract

Developing immunosuppressive therapies for autoimmune diseases comes with a caveat that immunosuppression may promote the risk of developing other conditions or diseases. We have previously shown that biolistic delivery of an expression construct encoding inducible HSP70 (HSP70i) with one amino acid modification in the dendritic cell (DC) activating moiety 435-445 (HSP70i

Indexed as

AutoimmunityAnimalsAntibodiesCell DegranulationCell Line, TumorDNA, NeoplasmHSP70 Heat-Shock ProteinsHumansKiller Cells, NaturalMaleMelanomaMiceMice, Inbred C57BLModels, BiologicalMutationSkin NeoplasmsAntibodiesDNA, NeoplasmHSP70 Heat-Shock ProteinsADCCAnti-tumorDendritic cellGene gunMelanomaVitiligo

Identifiers

PMID34542825
PMCPMC8492854
OpenAlexW3199742729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.