Evidence map›Paper›PMID 34542807›Full record

ReviewClinical reviews in allergy & immunology2022

Different Phenotypes in Asthma: Clinical Findings and Experimental Animal Models.

Luiz Otávio Lourenço, Alessandra Mussi Ribeiro, Fernanda Degobbi Tenório Quirino Dos Santos Lopes, Iolanda de Fátima Lopes Calvo Tibério, Wothan Tavares-de-Lima, Carla Máximo Prado

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical reviews in allergy & immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Association of maternal asthma with congenital heart defects in offspring.Acta obstetricia et gynecologica Scandinavica · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Mild allergic airways responses to an environmental mixture increase cardiovascular risk in rats.Toxicological sciences : an official journal of the Society of Toxicology · 2023
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Luiz Otávio LourençoDepartment of Biosciences, Federal University of São Paulo, Campus Baixada Santista, Santos, SP, Brazil.
Alessandra Mussi RibeiroDepartment of Biosciences, Federal University of São Paulo, Campus Baixada Santista, Santos, SP, Brazil.
Fernanda Degobbi Tenório Quirino Dos Santos LopesDepartment of Medicine, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Iolanda de Fátima Lopes Calvo TibérioDepartment of Medicine, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Wothan Tavares-de-LimaDepartment of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
Carla Máximo PradoDepartment of Biosciences, Federal University of São Paulo, Campus Baixada Santista, Santos, SP, Brazil. carla.prado@unifesp.br.ORCID http://orcid.org/0000-0003-1160-0442
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 303035/2018-8Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 2018/02537-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/06088-0
6 · The paper itself

Abstract

Asthma is a respiratory allergic disease presenting a high prevalence worldwide, and it is responsible for several complications throughout life, including death. Fortunately, asthma is no longer recognized as a unique manifestation but as a very heterogenic manifestation. Its phenotypes and endotypes are known, respectively, as pathologic and molecular features that might not be directly associated with each other. The increasing number of studies covering this issue has brought significant insights and knowledge that are constantly expanding. In this review, we intended to summarize this new information obtained from clinical studies, which not only allowed for the creation of patient clusters by means of personalized medicine and a deeper molecular evaluation, but also created a connection with data obtained from experimental models, especially murine models. We gathered information regarding sensitization and trigger and emphasizing the most relevant phenotypes and endotypes, such as Th2-

Indexed as

AsthmaHypersensitivityAnimalsBiomarkersHumansMiceModels, AnimalPhenotypeBiomarkersAnimal modelsAsthmaClinical dataPhenotypes

Identifiers

PMID34542807
OpenAlexW3201642154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.