Evidence map›Paper›PMID 34542773›Full record

ArticleBreast cancer research and treatment2021

Differential effects of CD20+ B cells and PD-L1+ immune cells on pathologic complete response and outcome: comparison between inflammatory breast cancer and locally advanced breast cancer patients.

Hugo Arias-Pulido, Ashley Marie Cimino-Mathews, Nabila Chaher, Clifford Ray Qualls, Nancy Joste, Cecile Colpaert, Jonathan Douglas Marotti, Mary Dickinson Chamberlin, Maxwell Gabriel Foisey, Eric Robert Prossnitz and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Hugo Arias-Pulido *Department of Microbiology, and Immunology and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, 621 Rubin Building-HB7936, 1 Medical Center Drive, Lebanon, NH, 03756, USA. hugo.ariaspulido@dartmouth.edu.ORCID http://orcid.org/0000-0003-4941-1110
Ashley Marie Cimino-Mathews *Departments of Pathology and Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nabila ChaherDepartment of Pathology, Centre Pierre et Marie Curie, EHS Salim Zemirli et Faculté de Médecine d'Alger, Université Alger 1, Algiers, Algeria.
Clifford Ray QuallsDepartment of Mathematics and Statistics, University of New Mexico, Albuquerque, NM, USA.
Nancy JosteDepartment of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Cecile ColpaertDepartment of Pathology, AZ Turnhout/UZ, Leuven, Belgium.
Jonathan Douglas MarottiDepartment of Pathology and Laboratory Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Mary Dickinson ChamberlinDepartment of Medical Oncology, and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Maxwell Gabriel FoiseyDepartment of Microbiology, and Immunology and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, 621 Rubin Building-HB7936, 1 Medical Center Drive, Lebanon, NH, 03756, USA.
Eric Robert ProssnitzDivision of Molecular Medicine, Department of Internal Medicine, Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Leisha Ann EmensUniversity of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA, USA.
Steven FieringDepartment of Microbiology, and Immunology and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, 621 Rubin Building-HB7936, 1 Medical Center Drive, Lebanon, NH, 03756, USA.
Dartmouth College · USUniversity of New Mexico · USCentre de Recherche Nucléaire d’Alger · DZJohns Hopkins University · USUniversitair Ziekenhuis Leuven · BEUPMC Hillman Cancer Center · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Monica Rosas Lemus · 2017 to 2026
$24.9M
Molecular Mechanisms and Applications of Novel ER/GPER-selective LigandsR01CA194496 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ARTERBURN, JEFFREY B, PROSSNITZ, ERIC R · 2016 to 2025
$4.1M
Dual-pronged nano-drug delivery using plant virus-like particles.R01CA224605 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Nicole Franziska Steinmetz · 2017 to 2026
$4.0M
G protein-coupled estrogen receptor GPER and breast carcinogenesisR01CA163890 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI PROSSNITZ, ERIC R · 2012 to 2023
$3.3M
Foundation for the National Institutes of Health CA163890Foundation for the National Institutes of Health CA194496Foundation for the National Institutes of Health R01CA224605GlaxoSmithKline No numberInternational Union Against Cancer ICR/09/0443NCI NIH HHS P30 CA023108NCI NIH HHS P30 CA118100NCI NIH HHS R01 CA163890NCI NIH HHS R01 CA194496NCI NIH HHS R01 CA224605NIGMS NIH HHS P20 GM121176
6 · The paper itself

Abstract

purposeThis study evaluated epidemiologic and immune factors associated with pathologic complete response (pCR), breast cancer-specific survival (BCSS) and disease-free survival (DFS) outcomes in inflammatory (IBC) and locally advanced breast cancer (LABC) patients.

methodsTumor-infiltrating lymphocytes (TILs) and CD20

resultsIBC and LABC display similar levels of TILs, CD20

conclusionCD20

Indexed as

Breast NeoplasmsInflammatory Breast NeoplasmsAntigens, CD20B7-H1 AntigenBiomarkers, TumorB-LymphocytesFemaleHumansLymphocytes, Tumor-InfiltratingPrognosisAntigens, CD20B7-H1 AntigenBiomarkers, TumorCD274 protein, humanCD20Immuno-oncologyInflammatory breast cancerLocally advanced breast cancerPatient outcomespCRPD-L1Tumor-infiltrating lymphocytes

Identifiers

PMID34542773
PMCPMC8603784
OpenAlexW3201037403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.