Evidence map›Paper›PMID 34542754›Full record

ArticleBulletin of experimental biology and medicine2021

Effect of Nitinol on Metabolic and Coagulation Activity of Endothelial Cells Culture.

R E Kalinin, I A Suchkov, N D Mzhavanadze, N V Korotkova, O N Zhurina, V O Povarov, I Yu Surov, A D Bozhenova, E A Strelnikova

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Adhesion of vessel wall to stentriever during combined technique for mechanical thrombectomy in acute ischemic stroke: A histomorphological study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

R E KalininRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
I A SuchkovRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
N D MzhavanadzeRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia. nina_mzhavanadze@mail.ru.
N V KorotkovaRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
O N ZhurinaRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
V O PovarovRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
I Yu SurovRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
A D BozhenovaRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
E A StrelnikovaRyazan State Medical University, Ministry of Health of the Russian Federation, Ryazan, Russia.
Ryazan State Medical University named after Academician I.P. Pavlov · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the effect of nitinol, the most prevalent material for endovascular stents, on metabolic and coagulation activity of a primary culture of human umbilical vein endothelial cells (HUVEC). Metabolic activity was evaluated using MTS-test and by the level of stable NO metabolites in the conditioned medium, coagulation activity was assessed by activity of von Willebrand factor (vWF) and levels of plasminogen activator inhibitor-1 (PAI-1) and soluble endothelial protein C receptors (sEPCR). Exposure to nitinol reduced metabolic activity of the cell culture by 11.1% in comparison with the control (p<0.001). Although absolute activity of vWF and absolute level of sEPCR were elevated, incubation with nitinol did not lead to a statistically significant elevation of these parameters in comparison with the control, which can indicate the absence of substantial hypercoagulation effects of nitinol.

Indexed as

AlloysBlood CoagulationBlood Coagulation FactorsCells, CulturedEndothelial Protein C ReceptorEndothelium, VascularHumansHuman Umbilical Vein Endothelial CellsPlasminogen Activator Inhibitor 1Thrombosisvon Willebrand FactorAlloysBlood Coagulation FactorsEndothelial Protein C ReceptornitinolPlasminogen Activator Inhibitor 1von Willebrand FactorHUVECnitinolPAI-1sEPCRvon Willebrand factor

Identifiers

PMID34542754
OpenAlexW3157688570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.