Evidence map›Paper›PMID 34542752›Full record

ArticleBulletin of experimental biology and medicine2021

Analysis of the Specificity of Auto-Reactive Antibodies to Individual Fragments of the Extracellular Domain of Desmoglein 3 in Patients with Pemphigus Vulgaris.

A A Kubanov, D G Deryabin, M V Shpilevaya, A E Karamova, A A Nikonorov, E N Larina, T K Aliev, D A Dolgikh, T V Bobik, I V Smirnov and 2 more

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

A A KubanovState Scientific Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia. nikonorov_all@mail.ru.
D G DeryabinState Scientific Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia.
M V ShpilevayaState Scientific Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia.
A E KaramovaState Scientific Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia.
A A NikonorovState Scientific Center for Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia.
E N LarinaM. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
T K AlievM. V. Lomonosov Moscow State University, Moscow, Russia.
D A DolgikhM. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
T V BobikM. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
I V SmirnovM. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
A G GabibovM. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
M P KirpichnikovM. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
Institute of Bioorganic Chemistry · RUMinistry of Health of the Russian Federation · RULomonosov Moscow State University · RUState Research Center for Dermatovenereology and Cosmetology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A method for the analysis of the epitope specificity of auto-reactive antibodies to desmoglein 3 (Dsg3) using competitive ELISA has been developed. It is based on a two-stage solid-phase ELISA with initial "depletion" of auto-reactive antibodies against the studied epitope and subsequent quantitative assessment of antibodies against full-length extracellular domain Dsg3. The proposed approach for assessing the specificity of the autoimmune response in patients with pemphigus vulgaris can provide in the future the possibility to personalize the therapy using plasmapheresis by preliminary selection of the antigenic composition of the extracorporeal immunosorbent.

Indexed as

AnimalsAntibody SpecificityAutoantibodiesCHO CellsCricetulusDesmoglein 3Enzyme-Linked Immunosorbent AssayEpitope MappingExtracellular SpaceHumansPemphigusPeptide FragmentsProtein DomainsAutoantibodiesDesmoglein 3Peptide Fragmentsautoantibodiesautoimmunitydesmoglein 3ELISApemphigus vulgarisspecificity

Identifiers

PMID34542752
OpenAlexW3157356077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.