Evidence map›Paper›PMID 34542725›Full record

SynthesisClinical oral investigations2021

Efficacy of hyaluronic acid for recurrent aphthous stomatitis: a systematic review of clinical trials.

Sadeq Ali Al-Maweri, Nader Alaizari, Rawan Hejji Alanazi, Sajna Ashraf, Rania Hejji Alanazi, Hesham Mohammed Al-Sharani, Esam Halboub

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Management of Recurrent Aphthous Stomatitis: An Indian Expert Consensus.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 5 countries.

Sadeq Ali Al-MaweriDepartment of Oral Medicine and Diagnostic Sciences, Vision College of Dentistry and Nursing, Riyadh, Saudi Arabia.
Nader AlaizariDepartment of Oral Medicine and Diagnostic Sciences, Vision College of Dentistry and Nursing, Riyadh, Saudi Arabia.
Rawan Hejji AlanaziDepartment of Oral and Maxillofacial Surgery, Vision College of Dentistry and Nursing, Riyadh, Saudi Arabia.
Sajna AshrafDepartment of Oral Medicine and Diagnostic Sciences, Vision College of Dentistry and Nursing, Riyadh, Saudi Arabia. drsajnaashraf@gmail.com.ORCID http://orcid.org/0000-0002-9153-6964
Rania Hejji AlanaziVision College of Dentistry and Nursing, Riyadh, Saudi Arabia.
Hesham Mohammed Al-SharaniDepartment of Oral and Maxillofacial Surgery, College of Dentistry, Ibb University, Ibb, Yemen.
Esam HalboubDepartment of Oral Medicine, Oral Pathology and Oral Radiology, Faculty of Dentistry, Sana'a University, Sana'a, Yemen.
Sion College · GBSana'a University · YEHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesRecurrent aphthous stomatitis (RAS) is a very common oral mucosal disease, and its management is quite challenging with no definitive cure being available so far. Many studies have tried hyaluronic acid (HA) for alleviating signs and symptoms of RAS. The present systematic review sought to assess the available evidence regarding the efficacy of HA in management of RAS.

methodsTwo reviewers independently conducted extensive search in four online databases (PubMed, Scopus, Web of Science, and Google Scholar) and the gray literature, with no restriction to date or language of the publication. All clinical trials that assessed the efficacy of HA in reducing signs and symptoms of RAS were included. Risk of bias was assessed by two reviewers independently, using the Cochrane assessment tool. Due to substantial heterogeneity, no meta-analysis was feasible.

resultsOut of the 75 identified articles, nine clinical trials involving 538 RAS patients (259 in HA group) were included. The risk of bias was high in five studies, low in one study, and unclear in three studies. The comparative groups varied greatly across the included studies: triamcinolone (in three studies), chlorhexidine mouthwash, lidocaine, placebo, iodine glycerin, diclofenac, and laser therapy. Overall, the results revealed a good efficacy of HA in alleviating pain and shortening the healing time of RAS, without any reported side effects. Compared to triamcinolone, HA showed superior results in one study, and comparable results in two studies.

conclusionsThe available evidence suggests that HA is a promising treatment option for RAS. However, given the huge heterogeneity of the included studies and high risk of bias in some of these studies, the evidence is inconclusive. Further well-designed clinical trials with standardized methodologies and adequate sample sizes are warranted to discern the efficacy of HA for RAS. CLINICAL RELEVANCE: Hyaluronic acid might be a viable alternative therapeutic option for patients with RAS.

Indexed as

Low-Level Light TherapyMouth DiseasesStomatitis, AphthousHumansHyaluronic AcidPainHyaluronic AcidAphthous stomatitisEfficacyHyaluronic acidManagement

Identifiers

PMID34542725
OpenAlexW3200930485

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.