Evidence map›Paper›PMID 34542695›Full record

ArticleEuropean radiology2022

Robustness of dual-energy CT-derived radiomic features across three different scanner types.

Simon Lennartz, Aileen O'Shea, Anushri Parakh, Thorsten Persigehl, Bettina Baessler, Avinash Kambadakone

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Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. [CT radiomicsZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
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  15. Article
  16. Review
  17. Development and validation ofEJNMMI research · 2022
    Article
  18. Quantitative dual-energy CT techniques in the abdomen.Abdominal radiology (New York) · 2022
    Review
  19. Quantitative dual-energy CT techniques in the abdomen.Abdominal radiology (New York) · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Simon LennartzDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, White 270, Boston, MA, 02114, USA.
Aileen O'SheaDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, White 270, Boston, MA, 02114, USA.
Anushri ParakhDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, White 270, Boston, MA, 02114, USA.
Thorsten PersigehlInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University Cologne, Kerpener Straße 62, 50937, Cologne, Germany.
Bettina BaesslerInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.
Avinash KambadakoneDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, White 270, Boston, MA, 02114, USA. akambadakone@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-6714-9190

Funding

Deutsche Forschungsgemeinschaft LE 4401/1-1 (Project number 426969820)
6 · The paper itself

Abstract

objectivesTo investigate the robustness of radiomic features between three dual-energy CT (DECT) systems.

methodsAn anthropomorphic body phantom was scanned on three different DECT scanners, a dual-source (dsDECT), a rapid kV-switching (rsDECT), and a dual-layer detector DECT (dlDECT). Twenty-four patients who underwent abdominal DECT examinations on each of the scanner types during clinical follow-up were retrospectively included (n = 72 examinations). Radiomic features were extracted after standardized image processing, following ROI placement in phantom tissues and healthy appearing hepatic, splenic and muscular tissue of patients using virtual monoenergetic images at 65 keV (VMI

resultsNone of the phantom-derived features attained the threshold for high feature robustness for any inter-scanner comparison. The proportion of robust features obtained from patients scanned on all three scanners was low both in VMI

conclusionsThe robustness of radiomic features across different DECT scanners in patients was low and the few robust patient-derived features were not reflected in the phantom experiment. Future efforts should aim to improve the cross-platform generalizability of DECT-derived radiomics. KEY POINTS: • Inter-scanner robustness of dual-energy CT-derived radiomic features was on a low level in patients who underwent clinical examinations on three DECT platforms. • The few robust patient-derived features were not confirmed in our phantom experiment. • Limited inter-scanner robustness of dual-energy CT derived radiomic features may impact the generalizability of models built with features from one particular dual-energy CT scanner type.

Indexed as

Radiography, Dual-Energy Scanned ProjectionHumansImage Processing, Computer-AssistedPhantoms, ImagingRetrospective StudiesTomography, X-Ray ComputedImage processing, computer-assistedReproducibility of resultsTomography, X-ray computed

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.