Evidence map›Paper›PMID 34542679›Full record

ArticleArchives of gynecology and obstetrics2022

Serum exosomal miRNA from endometriosis patients correlates with disease severity.

Yahong Wu, Wen Yuan, Hui Ding, Xianqing Wu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of gynecology and obstetrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 5 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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  17. miRNA expression haplotype in Hispanics with endometriosis.Frontiers in reproductive health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yahong Wu *Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, 139 Middle Renming Road, Changsha, 430011, Hunan, China.
Wen Yuan *Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, 139 Middle Renming Road, Changsha, 430011, Hunan, China.
Hui DingDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, 139 Middle Renming Road, Changsha, 430011, Hunan, China.
Xianqing WuDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, 139 Middle Renming Road, Changsha, 430011, Hunan, China. xianqing0302@csu.edu.cn.ORCID 0000-0002-7620-5796
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeExosomes are vesicles secreted by cells that contain a wide variety of biomolecules, including proteins or nucleic acids. MicroRNAs (miRNAs), which are commonly found in exosomes, are known to play important roles in the pathophysiology of endometriosis.

methodsThis study investigated the miRNA expression profile of serum exosomes from women with endometriosis in comparison with normal controls as well as the possible role of identified miRNAs in the pathogenesis of endometriosis. Exosomes with a diameter between 60 and 100 nm were identified by their expression of exosomal marker proteins CD9 and CD63.

resultsMicroarray miRNA expression profiling analysis revealed that 26 genes were significantly up-regulated and 19 genes were significantly down-regulated in serum exosomes from endometriosis patients compared with normal controls. These differentially expressed miRNAs were mainly enriched in the regulation of cellular development, metabolism, and involved in the regulation of the MAPK and PI3k-Akt pathways. qRT-PCR analysis verified the differential expression of three miRNAs, miR-26b-5p, miR-215-5p, and miR-6795-3p.

conclusionFurther analysis indicated that these differentially expressed miRNAs in serum exosomes may be involved in the pathogenesis of endometriosis and are related to the severity and certain symptoms of endometriosis.

Indexed as

EndometriosisExosomesMicroRNAsFemaleHumansSeverity of Illness IndexSignal TransductionMicroRNAsEndometriosisExosomal miRNAmiRNA chip

Identifiers

PMID34542679
PMCPMC8782809
OpenAlexW3200495353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.