Evidence map›Paper›PMID 34542671›Full record

Trial reportEuropean journal of applied physiology2021

Contralateral strength training attenuates muscle performance loss following anterior cruciate ligament (ACL) reconstruction: a randomised-controlled trial.

Claire Minshull, Peter Gallacher, Simon Roberts, Andrew Barnett, Jan Herman Kuiper, Andrea Bailey

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02722876 (The EFficacy of COntralateral Muscle Rehabilitation Exercise Following Anterior Cruciate Ligament Reconstruction), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02722876 nacompletednot on this map

The EFficacy of COntralateral Muscle Rehabilitation Exercise Following Anterior Cruciate Ligament Reconstruction (EFCOR)

TypeinterventionalSponsorRobert Jones and Agnes Hunt Orthopaedic and District NHS TrustRan2017 to 2019Enrolled44ConditionsMusculoskeletal SystemArmsContralateral Rehabilitation, Placebo flexibility exercise
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Functional rehabilitation strategies for enhancing neuromuscular control after ACL reconstruction: A systematic review.Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liao · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Claire MinshullResearch Department, RJAH Orthopaedic Hospital NHS Foundation Trust, Oswestry, SY10 7AG, UK. minshullc@hotmail.com.ORCID http://orcid.org/0000-0003-2924-882X
Peter GallacherResearch Department, RJAH Orthopaedic Hospital NHS Foundation Trust, Oswestry, SY10 7AG, UK.
Simon RobertsResearch Department, RJAH Orthopaedic Hospital NHS Foundation Trust, Oswestry, SY10 7AG, UK.
Andrew BarnettResearch Department, RJAH Orthopaedic Hospital NHS Foundation Trust, Oswestry, SY10 7AG, UK.
Jan Herman KuiperResearch Department, RJAH Orthopaedic Hospital NHS Foundation Trust, Oswestry, SY10 7AG, UK.
Andrea BaileyResearch Department, RJAH Orthopaedic Hospital NHS Foundation Trust, Oswestry, SY10 7AG, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the effects of cross-education (CE) exercise on strength and performance at 10 and 24 weeks post anterior cruciate ligament (ACL) surgery.

methodsDesign: randomised controlled trial. N = 44 ACL-reconstruction patients, randomly-allocated into: CE: strength training of the non-operative limb, or CON: sham exercise of upper limb stretching. Each patient underwent standardised ACL rehabilitation, plus 8 weeks of thrice weekly CE or CON, commencing at 2 weeks post surgery. The primary outcome was quadriceps peak force (QPF) of the ACL-reconstructed limb at 10 weeks post surgery. Secondary measures were hamstrings peak force (HPF), rate of force development (RFD) and International Knee Documentation Committee score (IKDC) at 10 and 24 weeks; QPF and hop for distance (HOP) at 24 weeks post surgery.

resultsCE significantly attenuated the decline in QPF of the ACL-reconstructed limb at 10 weeks compared to CON (16.6% decrease vs. 32.0%, respectively); that advantage was not retained at 24 weeks. A training effect was observed in the trained limb for HPF and QPF, which was retained at 24 weeks. No significant differences were observed for IKDC, HOP, RFD, or HPF of the reconstructed limb. Inter-limb symmetry (ILS) ranged from 0.78 to 0.89 and was not significantly different between groups.

conclusionHigh-intensity CE strength training attenuated the post-operative decline in QPF and should be considered in early-phase ACL rehabilitation. ILS data showed good symmetry, but it masked significantly inferior performance between groups and should be used with caution. TRIAL REGISTRATION NUMBER: NCT02722876.

Indexed as

Resistance TrainingAdultAnterior Cruciate Ligament ReconstructionFemaleHumansMaleMuscle StrengthCross-educationCross-transferRehabilitationStrength training

Identifiers

PMID34542671

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.