ArticleBiology of reproduction2021
Vaginal microbiota differences associated with pelvic organ prolapse risk during late gestation in commercial sows†.
Article in Biology of reproduction, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Structural and functional characteristics of faecal, vaginal and colostrum microbiota in high-yielding sows.Microbial genomics · 2026Article
- Spatiotemporal trends of pelvic organ prolapse incidence in North American swine breeding herds and association with climatic factors.Frontiers in veterinary science · 2026Article
- Evaluation of antibiotic usage during late gestation on pelvic organ prolapse incidence in sows.Translational animal science · 2026Article
- Early antimicrobial regimen shapes gut microbiota and health trajectories in pigs: a longitudinal study from weaning to finishing.Animal microbiome · 2025Article
- The sow vaginal and gut microbiota associated with longevity and reproductive performance.Journal of animal science and biotechnology · 2025Article
- Stage of pregnancy impacts the bacterial communities of reproductive and placental tissues in gilts.Journal of animal science · 2025Article
- Combined analysis of 16S rRNA gene sequencing data reveals core vaginal bacteria across livestock species.Frontiers in microbiology · 2025Article
- Effect of bardoxolone methyl on the lower reproductive tract microbiome in turkey breeder hens.Frontiers in physiology · 2025Article
- Bacterial profiles of the oral, vaginal, and rectal mucosa and colostrum of periparturient sows.PloS one · 2025Article
- In vitro biomechanical properties of porcine perineal tissues to better understand human perineal tears during delivery.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Evaluation of fecal microbiota of late gestation sows in relation to pelvic organ prolapse risk.Frontiers in microbiology · 2024Article
- Current practice in animal models for pelvic floor dysfunction.International urogynecology journal · 2023Review
- Reproductive Microbiomes in Domestic Livestock: Insights Utilizing 16S rRNA Gene Amplicon Community Sequencing.Animals : an open access journal from MDPI · 2023Review
- Identification of the genetic basis of sow pelvic organ prolapse.Frontiers in genetics · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last decade, sow mortality due to pelvic organ prolapse (POP) has increased. To better understand the biology associated with POP, sows were phenotypically assessed and assigned a perineal score (PS) based on presumed POP risk and categorized as PS1 (low), PS2 (moderate), or PS3 (high). The study objective was to identify changes in sow vaginal microbiota that may be associated with POP. The hypothesis is that vaginal microbiota differs between sows with variable risk for POP, and changes in microbiota during late gestation exist between sows with differing risk. Of the 2864 sows scored during gestation week 15, 1.0, 2.7, and 23.4% of PS1, PS2, and PS3 sows, respectively, subsequently experienced POP. Vaginal swabs subjected to 16S rRNA gene sequencing revealed differences in community composition (Bray-Curtis; P < 0.05) and individual operational taxonomic unit (OTU) comparisons between vaginal microbiota of PS1 and PS3 sows at gestation week 15. Further, differences (P < 0.05) in community composition and OTUs (Q < 0.05) were observed in PS3 sows that either did or did not subsequently experience POP. Differences in community structure (alpha diversity measurements; P < 0.05), composition (P < 0.05), and OTUs (Q < 0.05) were observed in gestation week 12 sows scored PS1 compared to week 15 sows scored PS1 or PS3, suggesting that sow vaginal microbiota shifts during late gestation differently as POP risk changes. Collectively, these data demonstrate that sows with greater POP risk have unique vaginal microflora, for which a better understanding could aid in the development of mitigation strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.