Evidence map›Paper›PMID 34541999›Full record

ArticleRenal failure2021

Hypophosphatemia is an independent risk factor for AKI among hospitalized patients with COVID-19 infection.

Zijin Chen, Chenni Gao, Haijin Yu, Lin Lu, Jialin Liu, Wei Chen, Xiaogang Xiang, Hafiz Muhammad Jafar Hussain, Benjamin J Lee, Chuanlei Li and 29 more

Abstract readMulticenter StudyVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Zijin ChenDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Chenni GaoDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Haijin YuDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Lin LuDepartment of Nephrology, North Huashan Hospital, Fudan University, Shanghai, China.
Jialin LiuDepartment of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University, School of medicine, Shanghai, China.ORCID 0000-0001-8763-7351
Wei ChenDepartment of Pulmonary and Critical Care Medicine, Ruijin Hospital, Institute of Respiratory Diseases, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Xiaogang XiangDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Hafiz Muhammad Jafar HussainDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Benjamin J LeeHouston Kidney Consultants, Houston, TX, USA.
Chuanlei LiDepartment of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
Wenjie WeiDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Yuhan HuangDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Xiang LiDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Zhengying FangDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Shuwen YuDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Qinjie WengDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Yan OuyangDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Xiaofan HuDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Jun TongDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Jian LiuDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Li LinDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Mingyu LiuWuhan Ninth Hospital, Wuhan, China.
Xiaoman XuRenal Department, Wuhan Ninth Hospital, Wuhan, Hubei, China.
Dan LiuRadiology Department of Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
Yuan SongRenal Department of Renmin Hospital, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Xifeng LvRenal Department of Renmin Hospital, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Yixin ZhaClinical Research Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
Zhiyin YeDepartment of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
Tingting JiangDepartment of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
Jieshuang JiaDepartment of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
Xiaonong ChenDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Yufang BiDepartment of Endocrinology and Metabolism disease, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Jun XueDepartment of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
Nan ChenDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Weiguo HuDepartment of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cijiang John HeDivision of Nephrology, Mount Sinai School of Medicine, New York, NY, USA.
Huiming WangRenal Department of Renmin Hospital, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Jun LiuDepartment of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0003-4584-8200
Jingyuan XieDepartment of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study sought to investigate incidence and risk factors for acute kidney injury (AKI) in hospitalized COVID-19.

methodsIn this retrospective study, we enrolled 823 COVID-19 patients with at least two evaluations of renal function during hospitalization from four hospitals in Wuhan, China between February 2020 and April 2020. Clinical and laboratory parameters at the time of admission and follow-up data were recorded. Systemic renal tubular dysfunction was evaluated

resultsIn total, 823 patients were enrolled (50.5% male) with a mean age of 60.9 ± 14.9 years. AKI occurred in 38 (40.9%) ICU cases but only 6 (0.8%) non-ICU cases. Using forward stepwise Cox regression analysis, we found eight independent risk factors for AKI including decreased platelet level, lower albumin level, lower phosphorus level, higher level of lactate dehydrogenase (LDH), procalcitonin, C-reactive protein (CRP), urea, and prothrombin time (PT) on admission. For every 0.1 mmol/L decreases in serum phosphorus level, patients had a 1.34-fold (95% CI 1.14-1.58) increased risk of AKI. Patients with hypophosphatemia were likely to be older and with lower lymphocyte count, lower serum albumin level, lower uric acid, higher LDH, and higher CRP. Furthermore, serum phosphorus level was positively correlated with phosphate tubular maximum per volume of filtrate (TmP/GFR) (Pearson

conclusionThe AKI incidence was very low in non-ICU patients as compared to ICU patients. Hypophosphatemia is an independent risk factor for AKI in patients hospitalized for COVID-19 infection.

Indexed as

Acute Kidney InjuryChinaCOVID-19FemaleHospitalizationHumansHypophosphatemiaIncidenceIntensive Care UnitsKidney Function TestsMaleMiddle AgedPneumonia, ViralRetrospective StudiesRisk FactorsSARS-CoV-2acute kidney injuryCOVID-19hypophosphateproximal tubulerisk factors

Identifiers

PMID34541999
PMCPMC8462927

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.