Evidence map›Paper›PMID 34541898›Full record

ReviewPhysiological reviews2022

The science and engineering behind sensitized brain-controlled bionic hands.

Chethan Pandarinath, Sliman J Bensmaia

Abstract readReview
In one paragraph

Review in Physiological reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Distinct Neural Modes Carry Information About Attempted Grasp Timing and Force in the Sensorimotor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Integration of learned artificial sensation with vision during freely moving navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Aerosol Jet Printing for Neuroprosthetic Device Development.Bioengineering (Basel, Switzerland) · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. A Generalist Intracortical Motor Decoder.bioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Review
  20. In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chethan PandarinathDepartment of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia.ORCID 0000-0003-1241-1432
Sliman J BensmaiaDepartment of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois.ORCID 0000-0003-4039-9135

Funding

Interdisciplinary Engineering Career Development Center in Movement and Rehabilitation SciencesK12HD073945 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DEWALD, JULIUS P, REINKENSMEYER, DAVID JAY · 2012 to 2021
$7.9M
A Biomimetic Approach Towards a Dexterous NeuroprosthesisUH3NS107714 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BONINGER, MICHAEL L. · 2018 to 2023
$7.1M
Sensory mechanisms of manual dexterity and their application to neuroprostheticsR35NS122333 · NINDS · UNIVERSITY OF CHICAGO · PI HATSOPOULOS, NICHOLAS G · 2021 to 2024
$4.5M
Biomimetic Somatosensory Feedback through IntracorticalmicrostimulationR01NS095251 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BENSMAIA, SLIMAN, GRILL, WARREN M. · 2016 to 2020
$3.7M
NICHD NIH HHS K12 HD073945NINDS NIH HHS R01 NS095251NINDS NIH HHS R35 NS122333NINDS NIH HHS UH3 NS107714
6 · The paper itself

Abstract

Advances in our understanding of brain function, along with the development of neural interfaces that allow for the monitoring and activation of neurons, have paved the way for brain-machine interfaces (BMIs), which harness neural signals to reanimate the limbs via electrical activation of the muscles or to control extracorporeal devices, thereby bypassing the muscles and senses altogether. BMIs consist of reading out motor intent from the neuronal responses monitored in motor regions of the brain and executing intended movements with bionic limbs, reanimated limbs, or exoskeletons. BMIs also allow for the restoration of the sense of touch by electrically activating neurons in somatosensory regions of the brain, thereby evoking vivid tactile sensations and conveying feedback about object interactions. In this review, we discuss the neural mechanisms of motor control and somatosensation in able-bodied individuals and describe approaches to use neuronal responses as control signals for movement restoration and to activate residual sensory pathways to restore touch. Although the focus of the review is on intracortical approaches, we also describe alternative signal sources for control and noninvasive strategies for sensory restoration.

Indexed as

BionicsBrain-Computer InterfacesAnimalsBrainFeedback, SensoryHandHumansMovementTouch Perceptionartificial touchbrain-machine interfacesmotor controlneuroprostheticssensory feedback

Identifiers

PMID34541898
PMCPMC8742729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.