ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021
Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 101 citations in OpenAlex.
- Observational
- Social Isolation and Its Influencing Factors in Maintenance Haemodialysis Patients: A Latent Profile Analysis.Journal of advanced nursing · 2026Article
- Loneliness Biases Social Engagement Decisions: Evidence From Value-Based Choice Models.Annals of the New York Academy of Sciences · 2026Article
- Social interactions between people of same and different generations shape longitudinal changes in interpersonal neural synchrony, loneliness, and social connection.PLoS biology · 2026Article
- Loneliness and AI chatbot dependence in young adults: the mediating role of perceived social support.BMC psychology · 2026Article
- The Longitudinal Interplay Between Loneliness and Depressive Symptoms During Late Childhood: Cross-Lagged Panel Network Analyses.European journal of investigation in health, psychology and education · 2026Article
- Automatic speech analysis can predict loneliness.Scientific reports · 2026Article
- PTSD symptoms, loneliness, and amygdala volumes during pandemic social distancing associated with risk of suicidal ideation in trauma survivors with and without pre-pandemic PTSD.Journal of affective disorders reports · 2026Article
- Cardiac Synchrony During Collaborative Drawing: A Longitudinal Comparison of Same Generation and Intergenerational Dyads.Annals of the New York Academy of Sciences · 2026Article
- Adolescent depression recognition and symptom prediction based on multi-view EEG network: an exploratory study.Frontiers in psychiatry · 2026Article
- Loneliness as a sex-specific risk factor for cognitive aging.Frontiers in human neuroscience · 2026Review
- Association between loneliness and hippocampal responses to dynamic social stimuli in psychotic disorders.Psychological medicine · 2025Article
- The impact of loneliness on balance learning ability in aging patients with Parkinson's disease.BMC geriatrics · 2025Article
- Associations between cyberbullying victimization and cyberbullying: a three-wave longitudinal moderated mediation model.BMC psychology · 2025Article
- Evaluating the effects of a conditioning training paradigm on loneliness, socio-affective processing, and brain connectivity: a study protocol of a two-arm randomised controlled trial.BMC psychology · 2025Article
- The Moderating Effect of Social Capital on the Relationship Between Loneliness and Depression in Older Adults.Behavioral sciences (Basel, Switzerland) · 2025Article
- The alone team: How an alone mindset affects group processes.British journal of psychology (London, England : 1953) · 2025Article
- Leveraging AI-Driven Neuroimaging Biomarkers for Early Detection and Social Function Prediction in Autism Spectrum Disorders: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases.Neuroscience bulletin · 2025Review
- Neural correlates of personal space regulation in psychosis: role of the inferior parietal cortex.Molecular psychiatry · 2025Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Loneliness is a painful condition associated with increased risk for premature mortality. The formation of new, positive social relationships can alleviate feelings of loneliness, but requires rapid trustworthiness decisions during initial encounters and it is still unclear how loneliness hinders interpersonal trust. Here, a multimodal approach including behavioral, psychophysiological, hormonal, and neuroimaging measurements is used to probe a trust-based mechanism underlying impaired social interactions in loneliness. Pre-stratified healthy individuals with high loneliness scores (n = 42 out of a screened sample of 3678 adults) show reduced oxytocinergic and affective responsiveness to a positive conversation, report less interpersonal trust, and prefer larger social distances compared to controls (n = 40). Moreover, lonely individuals are rated as less trustworthy compared to controls and identified by the blinded confederate better than chance. During initial trust decisions, lonely individuals exhibit attenuated limbic and striatal activation and blunted functional connectivity between the anterior insula and occipitoparietal regions, which correlates with the diminished affective responsiveness to the positive social interaction. This neural response pattern is not mediated by loneliness-associated psychological symptoms. Thus, the results indicate compromised integration of trust-related information as a shared neurobiological component in loneliness, yielding a reciprocally reinforced trust bias in social dyads.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.