Evidence map›Paper›PMID 34541735›Full record

ArticleHuman brain mapping2021

A method to remove the influence of fixative concentration on postmortem T

Benjamin C Tendler, Feng Qi, Sean Foxley, Menuka Pallebage-Gamarallage, Ricarda A L Menke, Olaf Ansorge, Samuel A Hurley, Karla L Miller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Effects of Postmortem Intervals on Quantitative MRI in Unfixed and Fixed Swine Brain: Implications for Ex Vivo MRI Applications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Benjamin C TendlerWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford.ORCID 0000-0003-2095-8665
Feng QiWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford.
Sean FoxleyWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford.
Menuka Pallebage-GamarallageNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Ricarda A L MenkeWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford.
Olaf AnsorgeNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Samuel A HurleyWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford.
Karla L MillerWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford.

Funding

Department of HealthMedical Research Council MR/K02213X/1Medical Research Council MR/L022656/1Wellcome TrustWellcome Trust 202788/Z/16/ZWellcome Trust 203139/Z/16/Z
6 · The paper itself

Abstract

Formalin fixation has been shown to substantially reduce T

Indexed as

Models, TheoreticalTissue PreservationBrainDiagnosisDiffusion Tensor ImagingFixativesFormaldehydeHumansFixativesFormaldehyde7 Tdiffusion MRIfixative modellingformalinhistologypost-mortem human brainT2 mapping

Identifiers

PMID34541735
PMCPMC8596944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.