Evidence map›Paper›PMID 34541719›Full record

ArticleMycoses2022

COVID-19-associated subacute invasive pulmonary aspergillosis.

Satish Swain, Animesh Ray, Radhika Sarda, Surabhi Vyas, Gagandeep Singh, Pankaj Jorwal, Parul Kodan, Puneet Khanna, Immaculata Xess, Sanjeev Sinha and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Mycoses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. COVID-19 associated lung cavitary lesions: A case series.Caspian journal of internal medicine · 2024
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Efficacy of LD BioJournal of fungi (Basel, Switzerland) · 2022
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Satish SwainDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0001-9466-3531
Animesh RayDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-9434-5338
Radhika SardaDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Surabhi VyasDepartment of Radiology, All India Institute of Medical Sciences, New Delhi, India.
Gagandeep SinghDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
Pankaj JorwalDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Parul KodanDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Puneet KhannaDepartment of Anaesthesia and Critical Care, All India institute of Medical Sciences, New Delhi, India.
Immaculata XessDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
Sanjeev SinhaDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Naveet WigDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Anjan TrikhaDepartment of Anaesthesia and Critical Care, All India institute of Medical Sciences, New Delhi, India.
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThough invasive pulmonary aspergillosis is a well known complication of COVID-19 pneumonia, indolent forms of aspergillosis have been rarely described.

methodsWe prospectively collected the clinico-radio-microbiological data of 10 patients of subacute invasive pulmonary aspergillosis (SAIA), who presented to our hospital with recent history of COVID-19 pneumonia along with cavitary lung disease, positive IgG (against Aspergillus) with or without positive respiratory samples for Aspergillus spp.

resultThe mean age of presentation of SAIA was 50.7 ± 11.8 years. All the patients had recently recovered from severe COVID-19 illness with a mean duration of 29.2 ± 12 days from COVID-19 positivity. Cough was the predominant symptom seen in 8/10 (80%) patients followed by haemoptysis. 7/10 (70%) patients were known diabetic. While serum galactomannan was positive in 5/9 patients (55.5%), fungal culture was positive in 2/7 patients (28.5%) and polymerase chain reaction (PCR) for Aspergillus was positive in three patients. Eight (80%) patients presented with a single cavitary lesion; pseudoaneurysm of pulmonary artery was seen in two patients and post-COVID-19 changes were seen in all patients. All patients were treated with voriconazole, out of which four (40%) patients died during the follow-up period.

conclusionSAIA should be considered in the differential diagnosis of cavitating lung lesions in patients with recent history of COVID-19 in the background of steroid use with or without pre-existing diabetes.

Indexed as

COVID-19Invasive Pulmonary AspergillosisAdultAntibodies, FungalAspergillusHumansImmunoglobulin GMiddle AgedVoriconazoleAntibodies, FungalImmunoglobulin GVoriconazoleCOVID-19fungal infectionsteroidsubacute invasive pulmonary aspergillosis

Identifiers

PMID34541719
PMCPMC8662253
OpenAlexW3199516932

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.