Evidence map›Paper›PMID 34541703›Full record

ReviewAmerican journal of primatology2021

Improving rigor and reproducibility in nonhuman primate research.

Eliza Bliss-Moreau, Rama R Amara, Elizabeth A Buffalo, Ricki J Colman, Monica E Embers, John H Morrison, Ellen E Quillen, Jonah B Sacha, Charles T Roberts, National Primate Research Center Consortium Rigor and Reproducibility Working Group

Abstract readReview
In one paragraph

Review in American journal of primatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trajectory-based weight modeling distinguishes pathologic weight loss and predicts adverse events in nonhuman primate allogeneic kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eliza Bliss-MoreauCalifornia National Primate Research Center, Davis, California, USA.ORCID 0000-0002-0740-5612
Rama R AmaraDivision of Microbiology and Immunology, Yerkes National Primate Research Center, Atlanta, Georgia, USA.
Elizabeth A BuffaloWashington National Primate Research Center, Seattle, Washington, USA.ORCID 0000-0001-6326-9187
Ricki J ColmanWisconsin National Primate Research Center, Madison, Wisconsin, USA.ORCID 0000-0001-9706-0525
Monica E EmbersDivision of Immunology, Tulane National Primate Research Center, Covington, Louisiana, USA.ORCID 0000-0003-4051-7592
John H MorrisonCalifornia National Primate Research Center, Davis, California, USA.ORCID 0000-0002-8292-0964
Ellen E QuillenDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0003-2033-8693
Jonah B SachaDivisions of Pathobiology and Immunology (JS) and Cardiometabolic Health (CR), Oregon National Primate Research Center, Beaverton, Oregon, USA.
Charles T RobertsDivisions of Pathobiology and Immunology (JS) and Cardiometabolic Health (CR), Oregon National Primate Research Center, Beaverton, Oregon, USA.ORCID 0000-0003-1756-5772
National Primate Research Center Consortium Rigor and Reproducibility Working Group

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Neural circuit theory and trained recurrent network modeling of rapid learningU19NS107609 · NINDS · UNIVERSITY OF WASHINGTON · PI KNIGHT, ROBERT THOMAS · 2018 to 2022
$12.6M
Temporally coordinated activity in the primate hippocampus supporting memory formationR01MH117777 · NIMH · UNIVERSITY OF WASHINGTON · PI BUFFALO, ELIZABETH A · 2018 to 2022
$3.3M
NIH HHS P51 OD010425NIH HHS P51 OD011092NIH HHS P51 OD011104NIH HHS P51 OD011106NIH HHS P51 OD011107NIH HHS P51 OD011132NIH HHS P51 OD011133NIMH NIH HHS R01 MH117777NINDS NIH HHS U19 NS107609
6 · The paper itself

Abstract

Nonhuman primates (NHPs) are a critical component of translational/preclinical biomedical research due to the strong similarities between NHP and human physiology and disease pathology. In some cases, NHPs represent the most appropriate, or even the only, animal model for complex metabolic, neurological, and infectious diseases. The increased demand for and limited availability of these valuable research subjects requires that rigor and reproducibility be a prime consideration to ensure the maximal utility of this scarce resource. Here, we discuss a number of approaches that collectively can contribute to enhanced rigor and reproducibility in NHP research.

Indexed as

Biomedical ResearchPrimatesAnimalsDisease Models, AnimalReproducibility of Resultsbiomedical researchdata sharingnonhuman primatespreregistrationquality assurance

Identifiers

PMID34541703
PMCPMC8629848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.