Evidence map›Paper›PMID 34541542›Full record

ArticleACS applied polymer materials2021

Diffusion of Protein Molecules through Microporous Nanofibrous Polyacrylonitrile Membranes.

Cunyi Zhao, Yang Si, Shenghan Zhu, Kevin Bradley, Ameer Y Taha, Tingrui Pan, Gang Sun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied polymer materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cunyi ZhaoDepartment of Biological and Agricultural Engineering, University of California, Davis, CA 95616, USA.
Yang SiDepartment of Biological and Agricultural Engineering, University of California, Davis, CA 95616, USA.
Shenghan ZhuDepartment of Biological and Agricultural Engineering, University of California, Davis, CA 95616, USA.
Kevin BradleyDepartment of Biological and Agricultural Engineering, University of California, Davis, CA 95616, USA.
Ameer Y TahaDepartment of Food Science and Technology, University of California, Davis, CA 95616, USA.
Tingrui PanDepartment of Biomedical Engineering, University of California, Davis, CA 95616, USA.
Gang SunDepartment of Biological and Agricultural Engineering, University of California, Davis, CA 95616, USA.
University of California, Davis · US

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
NIEHS NIH HHS P42 ES004699
6 · The paper itself

Abstract

Porous nanofibrous membranes have ultrahigh specific surface areas and could be broadly employed in protein purification, enzyme immobilization, and biosensors with enhanced selectivity, sensitivity, and efficiency. However, large biomolecules, such as proteins, have hindered diffusion behavior in the micro-porous media, significantly reducing the benefits provided by the nanofibrous membranes. The study of protein diffusion in polyacrylonitrile (PAN) nanofibrous membranes produced under varied humidity and polymer concentration of electrospinning revealed that heterogeneous structures of the nanofibrous membranes possess much smaller effective pore sizes than the measured pore sizes, which significantly affects the diffusion of large molecules through the system though sizes of proteins and pH conditions also have great impacts. Only when the measured membrane pore size is at least 1000 times higher than the protein size, the diffusion behavior of the protein is predictable in the system. The results provide insights into the design and applications of proper nanofibrous materials for improved applications in protein purification and immobilizations.

Indexed as

diffusion coefficienteffective pore sizeMicro-porous structureNanofibrous membranepartition coefficientProtein diffusionProtein-polymer interaction

Identifiers

PMID34541542
PMCPMC8445001
OpenAlexW3129237616

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.