Evidence map›Paper›PMID 34541537›Full record

ArticleSchizophrenia bulletin open2021

Cerebellar Activation Deficits in Schizophrenia During an Eyeblink Conditioning Task.

Nancy B Lundin, Dae-Jin Kim, Rachel L Tullar, Alexandra B Moussa-Tooks, Jerillyn S Kent, Sharlene D Newman, John R Purcell, Amanda R Bolbecker, Brian F O'Donnell, William P Hetrick

Open access · goldAbstract read
In one paragraph

Article in Schizophrenia bulletin open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Deletion of the Voltage-Gated Calcium Channel Gene, CaCerebellum (London, England) · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Nancy B LundinDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.ORCID https://orcid.org/0000-0002-8771-7850
Dae-Jin KimDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Rachel L TullarDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Alexandra B Moussa-TooksDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.ORCID https://orcid.org/0000-0002-6778-8379
Jerillyn S KentDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Sharlene D NewmanDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
John R PurcellDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Amanda R BolbeckerDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.ORCID https://orcid.org/0000-0003-4286-6454
Brian F O'DonnellDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
William P HetrickDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Indiana University Bloomington · USUniversity of Alabama · USUniversity of Minnesota Medical Center · USVanderbilt University · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Cerebellar timing dysfunction in schizophreniaR01MH074983 · NIMH · TRUSTEES OF INDIANA UNIVERSITY · PI HETRICK, WILLIAM P · 2006 to 2016
$3.6M
Training in Clinical Translational Science: Maximizing the Public Health ImpactT32MH103213 · NIMH · TRUSTEES OF INDIANA UNIVERSITY · PI WILLIAM P HETRICK · 2015 to 2026
$3.4M
Indiana Clinical and Translational Sciences InstituteTL1TR001107 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$2.0M
Neural Oscillations in Schizophrenia and a Rat ModelR21MH091774 · NIMH · TRUSTEES OF INDIANA UNIVERSITY · PI O'DONNELL, BRIAN FRANCIS · 2010 to 2011
$421k
Neural Circuity of Risk Aversion and Reward Processing in Psychotic DisordersF31MH122122 · NIMH · TRUSTEES OF INDIANA UNIVERSITY · PI PURCELL, JOHN RANDALL · 2020 to 2020
$46k
NCATS NIH HHS TL1 TR001107NCATS NIH HHS UL1 TR001108NIMH NIH HHS F31 MH122122NIMH NIH HHS R01 MH074983NIMH NIH HHS R21 MH091774NIMH NIH HHS T32 MH103213
6 · The paper itself

Abstract

The cognitive dysmetria theory of psychotic disorders posits that cerebellar circuit abnormalities give rise to difficulties coordinating motor and cognitive functions. However, brain activation during cerebellar-mediated tasks is understudied in schizophrenia. Accordingly, this study examined whether individuals with schizophrenia have diminished neural activation compared to controls in key regions of the delay eyeblink conditioning (dEBC) cerebellar circuit (eg, lobule VI) and cerebellar regions associated with cognition (eg, Crus I). Participants with schizophrenia-spectrum disorders (

Indexed as

associative learningcerebellumfunctional magnetic resonance imagingpsychosis

Identifiers

PMID34541537
PMCPMC8443466
OpenAlexW3198894985

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.