ArticleEClinicalMedicine2021
Quantitative analysis of morphological and functional features in Meibography for Meibomian Gland Dysfunction: Diagnosis and Grading.
Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Comparison of clinical outcomes between intense pulsed light therapy using two different filters in meibomian gland dysfunction: prospective randomized study.Scientific reports · 2023Trial
- Ocular surface and meibomian gland changes following repeated exposure to 5% povidone-iodine during intravitreal injections.Eye (London, England) · 2026Article
- Dry eye detection based on multidimensional temporal features of fluorescein tear film videos.Quantitative imaging in medicine and surgery · 2026Article
- Eyelid and tear-film factors associated with contact lens discomfort symptom burden among wearers attending after-care in Kisumu County, Kenya: a clinic-based cross-sectional study.BMC ophthalmology · 2026Article
- Differential Characteristics, Mechanisms, and Clinical Strategies for Perioperative Dry Eye in Presenile Cataract and Age-Related Cataract.Healthcare (Basel, Switzerland) · 2026Review
- AI driven quantitative analysis of meibomian glands in children and adolescents: a benchmark dataset study.Eye and vision (London, England) · 2025Article
- Impact of definition of meibomian gland dysfunction on the frequency of MGD in dry eye disease from the DREAM© study.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2025Article
- Development and multicenter validation of an AI driven model for quantitative meibomian gland evaluation.NPJ digital medicine · 2025Article
- A modular and adaptable approach for automated morphological feature extraction in meibography images.Scientific reports · 2025Article
- Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Dry Eye Disease: A Systematic Review with Meta-analysis.Ophthalmology and therapy · 2025Article
- The repeatability of tests for dry eye signs and symptoms in the dry eye assessment and management (DREAM) study.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2025Article
- Quantitative evaluation of meibomian gland dysfunction via deep learning-based infrared image segmentation.Frontiers in artificial intelligence · 2025Article
- A new digital biomarker ofFrontiers in cell and developmental biology · 2025Article
- A Comparative Study of Intense Pulsed Light with Two Different Filters in Meibomian Gland Dysfunction: A Prospective Randomized Study.Journal of clinical medicine · 2025Article
- A novel nomogram to predict glucocorticoid response in thyroid-associated ophthalmopathy: findings from a pilot study.Endocrine · 2024Article
- Quantitative evaluation of morphological and functional changes in meibomian glands and lipid layer thickness in patients with and without keratoconus.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Meibography signal intensity as a novel image biomarker for meibomian gland function: evidence from cross-sectional and longitudinal analyses.Quantitative imaging in medicine and surgery · 2024Article
- Global research of artificial intelligence in eyelid diseases: A bibliometric analysis.Heliyon · 2024Article
- Meibomian Gland Shortening Is Associated With Altered Meibum Composition.Investigative ophthalmology & visual science · 2024Article
- Factors affecting long-term changes of meibomian gland in MGD patients.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo explore the performance of quantitative morphological and functional analysis in meibography images by an automatic meibomian glands (MGs) analyser in diagnosis and grading Meibomian Gland Dysfunction (MGD).
methodsA cross-sectional study collected 256 subjects with symptoms related to dry eye and 56 healthy volunteers who underwent complete ocular surface examination was conducted between January 1, 2019, and December 31, 2020. The 256 symptomatic subjects were classified into MGD group (n = 195) and symptomatic non-MGD group (n = 61). An automatic MGs analyser was used to obtained multi-parametric measurements in meibography images including the MGs area ratio (GA), MGs diameter deformation index (DI), MGs tortuosity index (TI), and MGs signal index (SI). Adjusted odds ratios (ORs) of the multi-parametric measurements of MGs for MGD, and the area under the receiver operating characteristic (AUC-ROC) curves of multi-parametric measurements for MGD diagnosing and grading were conducted.
findingsWhen consider age, sex, ocular surface condition together, the estimated ORs for DI was 1.62 (95% CI, 1.29-2.56), low-level SI was 24.34 (95% CI, 2.73-217.3), TI was 0.76(95% CI, 0.54-0.90), and GA was 0.86 (95% CI, 0.74-0.92) for MGD. The combination of DI-TI-GA-SI showed an AUC = 0.82 (
interpretationThe MGs area ratio, diameter deformation, tortuosity and signal intensity could be considered promising biomarkers for MGD diagnosis and objective grading.
fundingThis work was supported by the Key-Area Research and Development Program of Guangdong Province (No. 2019B010152001), the National Natural Science Foundation of China under Grant (81901788) and Guangzhou Science and Technology Program (202002030412).
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