Evidence map›Paper›PMID 34541411›Full record

ArticleBioactive materials2022

Covalent linkage of sulfated hyaluronan to the collagen scaffold Mucograft® enhances scaffold stability and reduces proinflammatory macrophage activation

Sarah Al-Maawi, Sandra Rother, Norbert Halfter, Karen M Fiebig, Juliane Moritz, Stephanie Moeller, Matthias Schnabelrauch, Charles James Kirkpatrick, Robert Sader, Hans-Peter Wiesmann and 3 more

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Collagen-Based Osteogenic Nanocoating of Microrough Titanium Surfaces.International journal of molecular sciences · 2022
    Article
  12. Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  13. Article
  14. Gelatin-grafted tubular asymmetric scaffolds promote ureteral regenerationFrontiers in bioengineering and biotechnology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Sarah Al-MaawiClinic for Maxillofacial and Plastic Surgery, Goethe University, Frankfurt Am Main, Germany.
Sandra RotherInstitute of Materials Science, Max Bergmann Center of Biomaterials, TU Dresden, Budapester Str. 27, 01069, Dresden, Germany.
Norbert HalfterInstitute of Materials Science, Max Bergmann Center of Biomaterials, TU Dresden, Budapester Str. 27, 01069, Dresden, Germany.
Karen M FiebigInstitute of Materials Science, Max Bergmann Center of Biomaterials, TU Dresden, Budapester Str. 27, 01069, Dresden, Germany.
Juliane MoritzInstitute of Materials Science, Max Bergmann Center of Biomaterials, TU Dresden, Budapester Str. 27, 01069, Dresden, Germany.
Stephanie MoellerBiomaterials Department, INNOVENT e.V., Prüssingstr. 27B, 07745, Jena, Germany.
Matthias SchnabelrauchBiomaterials Department, INNOVENT e.V., Prüssingstr. 27B, 07745, Jena, Germany.
Charles James KirkpatrickClinic for Maxillofacial and Plastic Surgery, Goethe University, Frankfurt Am Main, Germany.
Robert SaderClinic for Maxillofacial and Plastic Surgery, Goethe University, Frankfurt Am Main, Germany.
Hans-Peter WiesmannInstitute of Materials Science, Max Bergmann Center of Biomaterials, TU Dresden, Budapester Str. 27, 01069, Dresden, Germany.
Dieter ScharnweberInstitute of Materials Science, Max Bergmann Center of Biomaterials, TU Dresden, Budapester Str. 27, 01069, Dresden, Germany.
Vera HintzeInstitute of Materials Science, Max Bergmann Center of Biomaterials, TU Dresden, Budapester Str. 27, 01069, Dresden, Germany.
Shahram GhanaatiClinic for Maxillofacial and Plastic Surgery, Goethe University, Frankfurt Am Main, Germany.
Max Bergmann Zentrum für Biomaterialien · DEGoethe University Frankfurt · DEInnovent · DEUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sulfated glycosaminoglycans (sGAG) show interaction with biological mediator proteins. Although collagen-based biomaterials are widely used in clinics, their combination with high-sulfated hyaluronan (sHA3) is unexplored. This study aims to functionalize a collagen-based scaffold (Mucograft®) with sHA3 via electrostatic (sHA3/PBS) or covalent binding to collagen fibrils (sHA3+EDC/NHS). Crosslinking without sHA3 was used as a control (EDC/NHS Ctrl). The properties of the sHA3-functionalized materials were characterized.

Indexed as

Cellular reactionCollagenMultinucleated giant cellsSulfated hyaluronanWound healing

Identifiers

PMID34541411
PMCPMC8429620
OpenAlexW3174298148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.