ArticleBioactive materials2022
High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure.
Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Application of hydrogel technologies in the treatment of musculoskeletal disorders.Chinese medical journal · 2026Review
- Complex bioactive nanofibrous dura mater repairs traumatic brain injury.Neural regeneration research · 2026Article
- An Asymmetric Dura-Inspired Collagen Hydrogel Patch with Integrated Dense-Porous Architecture Enabled by Dual-Channel Freeze Casting.Advanced healthcare materials · 2026Article
- Acid-tolerant injectable bioadhesive for sutureless repair of large gastric perforation.Nature communications · 2026Article
- A dynamically adaptive wet-adhesive Janus hydrogel patch for sutureless repair of spinal dural defects.Bioactive materials · 2026Article
- Biomimetic trilayered silk-based electrospun scaffolds for regeneration of dura mater.RSC advances · 2025Article
- Designing hydrogel for application in spinal surgery.Materials today. Bio · 2025Review
- Janus adhesive bio-patches with targeted drug delivery enabled anti-bacteria and pro-angiogenesis for dura mater repair.Materials today. Bio · 2025Article
- Robust tetra-armed poly (ethylene glycol)-based hydrogel as tissue bioadhesive for the efficient repair of meniscus tears.MedComm · 2024Article
- A low-swelling hydrogel as a multirole sealant for efficient dural defect sealing and prevention of postoperative adhesion.National science review · 2024Article
- Matrix Metalloproteinase-Responsive Hydrogel with On-Demand Release of Phosphatidylserine Promotes Bone Regeneration Through Immunomodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A tough bioadhesive hydrogel supports sutureless sealing of the dural membrane in porcine and ex vivo human tissue.Science translational medicine · 2024Article
- Flexible Fabrication and Hybridization of Bioactive Hydrogels with Robust Osteogenic Potency.Pharmaceutics · 2023Article
- Fabrication of Injectable Kartogenin-Conjugated Composite Hydrogel with a Sustained Drug Release for Cartilage Repair.Pharmaceutics · 2023Article
- In situ-formable, dynamic crosslinked poly(ethylene glycol) carrier for localized adeno-associated virus infection and reduced off-target effects.Communications biology · 2023Article
- Clinical management of dural defects: A review.World journal of clinical cases · 2023Review
- Facile Construction of Hybrid Hydrogels with High Strength and Biocompatibility for Cranial Bone Regeneration.Gels (Basel, Switzerland) · 2022Article
- CXCR4-guided liposomes regulating hypoxic and immunosuppressive microenvironment for sorafenib-resistant tumor treatment.Bioactive materials · 2022Article
- A hydrogel spinal dural patch with potential anti-inflammatory, pain relieving and antibacterial effects.Bioactive materials · 2022Article
- Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural Substitute to Prevent Post-Surgical Adhesion.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in meticulous dural closure technique remain a great challenge for watertight dural closure in the aged society, because the cerebrospinal fluid (CSF) leakage after spinal surgery is often accompanied with the disgusting wound infection, meningitis and pseudomeningocele. Here, a tetra-poly (ethylene glycol) (PEG)-based hydrogel sealant is developed with collective advantages of facile operation, high safety, quick set time, easy injectability, favorable mechanical strength and powerful tissue adhesion for effective sutureless dural closure during the surgery procedure. Impressively, this tetra-PEG sealant can instantaneously adhere to the irregular tissue surfaces even in a liquid environment, and effectively prevent or block off the intraoperative CSF leakage for sutureless dural closure and dura regeneration. Together, this sutureless tetra-PEG adhesive can be utilized as a very promising alternative for high-efficient watertight dural closure of the clinical patients who incidentally or deliberately undergo the durotomy during the spinal surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.