ArticleBiochemistry and biophysics reports2021
Single-cell tracking reveals super-spreading brain cancer cells with high persistence.
Article in Biochemistry and biophysics reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Aggressive Glioblastoma Cells Enhance the Migratory Persistence and Velocity of Less Aggressive Cells to Promote Tumor Dissemination.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Long-term tracing of individual human neural cells using multiphoton microscopy and photoconvertible polymer capsules.Journal of the Royal Society, Interface · 2024Article
- Intracellular biocompatible hexagonal boron nitride quantum emitters as single-photon sources and barcodes.Nanoscale · 2024Article
- Research of restricted migration evaluation of MDA-MB-231 cells in 2D and 3D co-culture models.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Instant processing of large-scale image data with FACT, a real-time cell segmentation and tracking algorithm.Cell reports methods · 2023Article
- Microcavity- and Microlaser-Based Optical Barcoding: A Review of Encoding Techniques and Applications.ACS photonics · 2023Review
- Immunostaining protocol for infiltrating brain cancer spheroids for light-sheet imaging.PloS one · 2023Article
- 3D models of glioblastoma interaction with cortical cells.Frontiers in bioengineering and biotechnology · 2023Article
- Distinct speed and direction memories of migrating dendritic cells diversify their search strategies.Biophysical journal · 2022Article
- Tumor spheroids accelerate persistently invading cancer cells.Scientific reports · 2022Article
- Single-cell tracking reveals super-spreading brain cancer cells with high persistence.Biochemistry and biophysics reports · 2021Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell migration is a fundamental characteristic of vital processes such as tissue morphogenesis, wound healing and immune cell homing to lymph nodes and inflamed or infected sites. Therefore, various brain defect diseases, chronic inflammatory diseases as well as tumor formation and metastasis are associated with aberrant or absent cell migration. We embedded multicellular brain cancer spheroids in Matrigel™ and utilized single-particle tracking to extract the paths of cells migrating away from the spheroids. We found that - in contrast to local invasion - single cell migration is independent of Matrigel™ concentration and is characterized by high directionality and persistence. Furthermore, we identified a subpopulation of super-spreading cells with >200-fold longer persistence times than the majority of cells. These results highlight yet another aspect of cell heterogeneity in tumors.
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