Evidence map›Paper›PMID 34541301›Full record

ArticleSmall methods2021

A Hybrid Nanofiber/Paper Cell Culture Platform for Building a 3D Blood-brain Barrier Model.

Kaixiang Huang, Andre Castiaux, Ram Podicheti, Douglas B Rusch, R Scott Martin, Lane A Baker

Open access · greenAbstract read
In one paragraph

Article in Small methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Vascularizing the brainiScience · 2022
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kaixiang HuangDepartment of Chemistry, Indiana University Bloomington, 800 E. Kirkwood Avenue, Bloomington, Indiana 47405, USA.
Andre CastiauxDepartment of Chemistry and Center for Additive Manufacturing, Saint Louis University, 3501 Laclede Avenue, St. Louis, Missouri 63103, USA.
Ram PodichetiCenter for Genomics and Bioinformatics, Indiana University Bloomington, 1001 East Third St., Bloomington, Indiana 47405, USA.
Douglas B RuschCenter for Genomics and Bioinformatics, Indiana University Bloomington, 1001 East Third St., Bloomington, Indiana 47405, USA.
R Scott MartinDepartment of Chemistry and Center for Additive Manufacturing, Saint Louis University, 3501 Laclede Avenue, St. Louis, Missouri 63103, USA.
Lane A BakerDepartment of Chemistry, Indiana University Bloomington, 800 E. Kirkwood Avenue, Bloomington, Indiana 47405, USA.
Indiana University Bloomington · USSaint Louis University · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
From single molecule to microfluidic 3D tissue platforms: novel multiscale tools to investigate hyper-stimulated immune cells in the circulationR01NS105888 · NINDS · MICHIGAN STATE UNIVERSITY · PI Lane A. Baker, ROBERT Scott MARTIN · 2018 to 2026
$4.0M
NCATS NIH HHS UL1 TR002529NINDS NIH HHS R01 NS105888
6 · The paper itself

Abstract

The blood brain barrier (BBB) protects the central nervous system from toxins and pathogens in the blood by regulating permeation of molecules through the barrier interface.

Indexed as

3D cell cultureblood-brain barriergene expression analysisinduced pluripotent stem cellpaper/nanofiber-based cell culture

Identifiers

PMID34541301
PMCPMC8445000
OpenAlexW3194557514

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.