Evidence map›Paper›PMID 34541284›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021

Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments.

Anja Ophey, Steffen Wolfsgruber, Sandra Roeske, Alexandra Polcher, Annika Spottke, Lutz Frölich, Michael Hüll, Frank Jessen, Johannes Kornhuber, Wolfgang Maier and 21 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Evaluation of Differential Diagnostics Potential of Uniform Data Set 2 Neuropsychology Battery Using Alzheimer's Disease Biomarkers.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Anja OpheyDepartment of Medical Psychology Neuropsychology & Gender Studies; Center for Neuropsychological Diagnostics and Intervention (CeNDI) Faculty of Medicine and University Hospital Cologne, University of Cologne Cologne Germany.
Steffen WolfsgruberDepartment of Neurodegenerative Diseases and Gerontopsychiatry University Hospital of Bonn University of Bonn Bonn Germany.
Sandra RoeskeDepartment of Neurodegenerative Diseases and Gerontopsychiatry University Hospital of Bonn University of Bonn Bonn Germany.
Alexandra PolcherDepartment of Neurodegenerative Diseases and Gerontopsychiatry University Hospital of Bonn University of Bonn Bonn Germany.
Annika SpottkeGerman Center for Neurodegenerative Diseases (DZNE) Bonn Germany.
Lutz FrölichDepartment of Geriatric Psychiatry Central Institute of Mental Health Medical Faculty Mannheim University of Heidelberg Heidelberg Germany.
Michael HüllEmmendingen Center for Psychiatry and Department of Psychiatry and Psychotherapy University of Freiburg Emmendingen Germany.
Frank JessenDepartment of Psychiatry and Psychotherapy Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.
Johannes KornhuberDepartment of Psychiatry and Psychotherapy University Erlangen Erlangen Germany.
Wolfgang MaierDepartment of Psychiatry University Hospital of Bonn University of Bonn Bonn Germany.
Oliver PetersDepartment of Psychiatry Charité - Universitätsmedizin Berlin Berlin Germany.
Alfredo RamirezDepartment of Neurodegenerative Diseases and Gerontopsychiatry University Hospital of Bonn University of Bonn Bonn Germany.
Jens WiltfangClinic for Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany.
Inga Liepelt-ScarfoneHertie Institute for Clinical Brain Research Department of Neurodegenerative Diseases Tübingen Germany.
Sara BeckerHertie Institute for Clinical Brain Research Department of Neurodegenerative Diseases Tübingen Germany.
Daniela BergHertie Institute for Clinical Brain Research Department of Neurodegenerative Diseases Tübingen Germany.
Jörg B SchulzDepartment of Neurology RWTH Aachen University Aachen Germany.
Kathrin ReetzDepartment of Neurology RWTH Aachen University Aachen Germany.
Jennifer WojtalaDepartment of Neurology RWTH Aachen University Aachen Germany.
Jan KassubekDepartment of Neurology University of Ulm Ulm Germany.
Alexander StorchDepartment of Neurology University of Rostock and German Center for Neurodegenerative Diseases (DZNE) Rostock Germany.
Monika Balzer-GeldsetzerEthikkommission Ludwig-Maximilians-Universität München München Germany.
Rüdiger Hilker-RoggendorfDepartment of Neurology Klinikum Vest Recklinghausen Germany.
Karsten WittDepartment of Neurology and Research Centre of Neurosensory Sciences Carl von Ossietzky University Oldenburg Germany.
Brit MollenhauerParacelsus-Elena Klinik, Kassel Department of Neurosurgery University Medical Center, Goettingen Kassel Germany.
Claudia TrenkwalderParacelsus-Elena Klinik, Kassel Department of Neurosurgery University Medical Center, Goettingen Kassel Germany.
Hans-Ullrich WittchenDepartment of Psychiatry & Psychotherapy University Hospital Munich Ludwig-Maximilians-University Munich Munich Germany.
Oliver RiedelDepartment of Clinical Epidemiology Leibniz Institute for Prevention Research and Epidemiology - BIPS Achterstraße 30 Bremen Germany.
Richard DodelDepartment of Neurology Philipps University Marburg Baldingerstraße Marburg Germany.
Michael WagnerDepartment of Neurodegenerative Diseases and Gerontopsychiatry University Hospital of Bonn University of Bonn Bonn Germany.
Elke KalbeDepartment of Medical Psychology Neuropsychology & Gender Studies; Center for Neuropsychological Diagnostics and Intervention (CeNDI) Faculty of Medicine and University Hospital Cologne, University of Cologne Cologne Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLarge studies on cognitive profiles of patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD-MCI) compared to Parkinson's disease (PD-MCI) are rare.

methodsData from two multicenter cohort studies in AD and PD were merged using a unified base rate approach for the MCI diagnosis. Cognitive profiles were compared using scores derived from the Consortium to Establish a Registry for Alzheimer's Disease battery.

resultsPatients with AD-MCI showed lower standardized scores on all memory test scores and a language test. Patients with PD-MCI showed lower standardized scores in a set-shifting measure as an executive task. A cross-validated logistic regression with test scores as predictors was able to classify 72% of patients correctly to AD-MCI versus PD-MCI. DISCUSSION: The applied test battery successfully discriminated between AD-MCI and PD-MCI. Neuropsychological test batteries in clinical practice should always include a broad spectrum of cognitive domains to capture any cognitive changes.

Indexed as

Alzheimer's diseasecognitive profilesConsortium to establish a registry for Alzheimer's disease test batterymild cognitive impairmentneuropsychological assessmentParkinson's disease

Identifiers

PMID34541284
PMCPMC8438680

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.