ArticleBio-protocol2017
Spinal Cord Preparation from Adult Red-eared Turtles for Electrophysiological Recordings during Motor Activity.
Article in Bio-protocol, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord.Nature communications · 2019Article
- Neuronal Population Activity in Spinal Motor Circuits: Greater Than the Sum of Its Parts.Frontiers in neural circuits · 2017Review
- Intense Activity of the Raphe Spinal Pathway Depresses Motor Activity via a Serotonin Dependent Mechanism.Frontiers in neural circuits · 2017Article
- Lognormal firing rate distribution reveals prominent fluctuation-driven regime in spinal motor networks.eLife · 2016Article
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Authors and funding
2 authors.
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Abstract
Although it is known that the generation of movements is performed to a large extent in neuronal circuits located in the spinal cord, the involved mechanisms are still unclear. The turtle as a model system for investigating spinal motor activity has advantages, which far exceeds those of model systems using other animals. The high resistance to anoxia allows for investigation of the fully developed and adult spinal circuitry, as opposed to mammals, which are sensitive to anoxia and where using neonates are often required to remedy the problems. The turtle is mechanically stable and natural sensory inputs can induce multiple complex motor behaviors, without the need for application of neurochemicals. Here, we provide a detailed protocol of how to make the adult turtle preparation, also known as the integrated preparation for electrophysiological investigation. Here, the hind-limb scratch reflex can be induced by mechanical sensory activation, while recording single cells, and the network activity, via intracellular-, extracellular- and electroneurogram recordings. The preparation was developed for the studies by Petersen
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