Evidence map›Paper›PMID 34541033›Full record

ArticleAmerican journal of clinical and experimental urology2021

Loss of CDCP1 triggers FAK activation in detached prostate cancer cells.

Sara G Pollan, Pai-Chi Teng, Yu Jen Jan, Julie Livingstone, Cai Huang, Minhyung Kim, Javier Mariscal, Maria Rodriguez, Jie-Fu Chen, Sungyong You and 12 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of clinical and experimental urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 2 countries.

Sara G PollanDepartment of Surgery, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Pai-Chi TengDepartment of Surgery, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Yu Jen JanDepartment of Surgery, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Julie LivingstoneDepartment of Informatics and Biocomputing, Ontario Institute for Cancer Research Toronto, ON M5G 1L7, Canada.
Cai HuangDepartment of Pharmacology and Nutritional Sciences, Markey Cancer Center, University of Kentucky 789 South Limestone St, Lexington, KY 40536, USA.
Minhyung KimDepartment of Surgery, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Javier MariscalDepartment of Surgery, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Maria RodriguezDepartment of Surgery, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Jie-Fu ChenDepartment of Surgery, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Sungyong YouDepartment of Surgery, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Dolores DiVizioDepartment of Surgery, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Paul C BoutrosDepartment of Human Genetics and Urology, Jonsson Comprehensive Cancer Centre, University of California Los Angeles, CA, USA.
Keith Syson ChanDepartment of Pathology, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Olga RasorenovaDepartment of Molecular Biology and Biochemistry, University of California Irvine Irvine, CA 92697, USA.
Anne CressDepartment of Cellular and Molecular Medicine, University of Arizona College of Medicine 1501 N, Campbell Avenue, Tucson, AZ 85724, USA.
Danislav SpassovDepartment of Medicine, University of California San Francisco San Francisco, CA 94143, USA.
Mark MoasserDepartment of Medicine, University of California San Francisco San Francisco, CA 94143, USA.
Edwin M PosadasDepartment of Medicine, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Stephen J FreedlandDepartment of Surgery, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Michael R FreemanDepartment of Surgery, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Jie J ZhengDepartment of Cell & Developmental Biology, University of California Los Angeles CHS BH-973B, Los Angeles, CA 90095, USA.
Beatrice S KnudsenDepartment of Biomedical Sciences, Cedars-Sinai Medical Center 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Cedars-Sinai Medical Center · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USMarkey Cancer Center · USOntario Institute for Cancer Research · CAUniversity of Arizona · USUniversity of California, Irvine · US

Funding

Prostate Cancer Bone Metastasis: Biology and TargetingP01CA098912 · NCI · EMORY UNIVERSITY · PI CHUNG, LELAND W.K. · 2003 to 2019
$24.0M
In vivo effects of sulforaphane supplementation on normal human prostateR01CA131255 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KNUDSEN, BEATRICE S, LIN, DANIEL W. · 2009 to 2013
$1.8M
NCI NIH HHS P01 CA098912NCI NIH HHS R01 CA131255
6 · The paper itself

Abstract

A major metastasis suppressing mechanism is the rapid apoptotic death of cancer cells upon detachment from extracellular matrix, a process called anoikis. Focal adhesion kinase (PTK2/FAK) is a key enzyme involved in evasion of anoikis. We show that loss of the Cub-domain containing protein-1 (CDCP1), paradoxically stimulates FAK activation in the detached state of prostate cancer cells. In CDCP1

Indexed as

anoikisCDCP1focal adhesion kinasePIP5K1cprostate cancer metastasis

Identifiers

PMID34541033
PMCPMC8446766
OpenAlexW3200619442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.