Evidence map›Paper›PMID 34540841›Full record

ArticleFrontiers in cell and developmental biology2021

Mechanical Stimulation

Benjamin E Peterson, Rebecca A Rolfe, Allen Kunselman, Paula Murphy, Spencer E Szczesny

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The LINC Complex Regulates Tendon Elastic Modulus, Collagen Crimp, and Lateral Expansion During Early Postnatal Development.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  8. Article
  9. Article
  10. Reduction in postnatal weight-bearing does not alter the trajectory of murine meniscus growth and maturation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024
    Article
  11. Embryo movement is required for limb tendon maturation.Frontiers in cell and developmental biology · 2024
    Article
  12. Article
  13. Mechanochemistry of collagen.Acta biomaterialia · 2023
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Benjamin E PetersonDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA, United States.
Rebecca A RolfeDepartment of Zoology, School of Natural Sciences, Trinity College Dublin, The University of Dublin, Dublin, Ireland.
Allen KunselmanDepartment of Public Health Science, Division of Biostatistics and Bioinformatics, Pennsylvania State University, Hershey, PA, United States.
Paula MurphyDepartment of Zoology, School of Natural Sciences, Trinity College Dublin, The University of Dublin, Dublin, Ireland.
Spencer E SzczesnyDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA, United States.
Pennsylvania State University · USTrinity College Dublin · IEPenn State Milton S. Hershey Medical Center · US

Funding

Studying Mechanotransduction in Late Embryonic Development to Inform Tendon Tissue EngineeringR21AR075941 · NIAMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SZCZESNY, SPENCER · 2019 to 2020
$346k
NIAMS NIH HHS R21 AR075941
6 · The paper itself

Abstract

During embryonic development, tendons transform into a hypocellular tissue with robust tensile load-bearing capabilities. Previous work suggests that this mechanical transformation is due to increases in collagen fibril length and is dependent on mechanical stimulation

Indexed as

chick embryocollagen fibrilmechanical stimulationmultiscale mechanicstendon development

Identifiers

PMID34540841
PMCPMC8446456
OpenAlexW3197754787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.