Evidence map›Paper›PMID 34540708›Full record

ArticleEuropean thyroid journal2021

Metabolic Changes after Radioiodine Correction of Grade 1 and Grade 2 Subclinical Hyperthyroidism.

Lucia Russo, Thi Ngoc Huyen Nguyen, Aglaia Kyrilli, Martin Robin, Pierre Bel Lassen, Rodrigo Moreno-Reyes, Bernard Corvilain

Open access · bronzeAbstract read
In one paragraph

Article in European thyroid journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Lucia RussoDepartment of Medicine, DIMED, Internal Medicine 3, University of Padua, Padova, Italy.
Thi Ngoc Huyen NguyenDepartment of Endocrinology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Aglaia KyrilliDepartment of Endocrinology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Martin RobinDepartment of Nuclear Medicine, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Pierre Bel LassenDepartment of Urology, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Brussels, Belgium.
Rodrigo Moreno-ReyesUMRS 1166 (Inserm), Paris, France.
Bernard CorvilainDepartment of Endocrinology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Université Libre de Bruxelles · BEInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEndogenous subclinical hyperthyroidism (eSCH) is defined by subnormal serum thyroid-stimulating hormone (TSH) level. There is limited evidence of metabolic changes induced by eSCH. The aim of our work was to evaluate changes in BMI and lipid parameters after radioiodine treatment in patients with grade 1 (TSH: 0.1-0.39 mlU/L) and 2 (TSH <0.1 mlU/L) eSCH.

designA retrospective study was performed on 74 patients with eSCH caused by benign autonomous nodular goiter which was treated with radioiodine.

methodsWe assessed BMI, lipids parameters, and TSH after radioiodine therapy. The 12-month follow-up time point was used to compare the primary outcome variables. TSH was measured by the electrochemiluminescence method.

resultsAfter radioiodine therapy, the absolute and relative increases in BMI at 12 months were significantly higher in the grade 2 group than in the grade 1 group (1.07 ± 0.27 kg/m

conclusionsAfter correction of eSCH, increases in BMI and LDL levels were observed only in patients with grade 2 eSCH. Pretreatment serum TSH was the main independent factor associated with BMI changes after radioiodine treatment.

Indexed as

BMIHyperthyroidismLipidsMultinodular goiter

Identifiers

PMID34540708
PMCPMC8406254
OpenAlexW3121269302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.