SynthesisEuropean thyroid journal2021
The Efficacy and Short- and Long-Term Side Effects of Radioactive Iodine Treatment in Pediatric Graves' Disease: A Systematic Review.
Synthesis in European thyroid journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- The EANM guideline on radioiodine therapy of benign thyroid disease.European journal of nuclear medicine and molecular imaging · 2023Guideline
- 2022 European Thyroid Association Guideline for the management of pediatric Graves' disease.European thyroid journal · 2022Guideline
- Efficacy and safety of ultrasound-guided microwave "Near-Total Ablation" for refractory hyperthyroidism: a retrospective study.Frontiers in endocrinology · 2026Article
- Process to radioactive iodine treatment for Graves' hyperthyroidism: condemned or absolved?Journal of endocrinological investigation · 2025Review
- Comparing antithyroid drugs vs. radioactive iodine in paediatric Graves' disease: literature review.Thyroid research · 2025Review
- Quality of Life Outcomes Following Radioactive lodine 131 Therapy in Hyperthyroid Patients: Insights from the Thyroid Patient-Reported Outcome Questionnaire.Molecular imaging and radionuclide therapy · 2025Article
- From data to decision: an interpretable machine learning model for optimizing RAI therapy in Graves' hyperthyroidism.Frontiers in endocrinology · 2025Article
- A Belgian single centre outcome study of radioiodine treatment in adolescents with Graves' disease.Scientific reports · 2024Article
- Ultrasound-guided microwave ablation combined with Lugol's solution for preoperative preparation in the treatment of refractory pediatric hyperthyroidism: a description of two cases.Quantitative imaging in medicine and surgery · 2024Article
- Article
- Updates in the Management of Graves Disease in Children.Ewha medical journal · 2023Review
- Thyroid volume is the key predictor of hyperthyroidism remission after radioactive iodine therapy in pediatric patients.European journal of pediatrics · 2023Observational
- Graves' disease: moving forwards.Archives of disease in childhood · 2023Review
- Graves' Disease in Children: An Update.Clinical medicine insights. Endocrinology and diabetes · 2023Review
- Outcomes of Radioactive Iodine (Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGraves's disease (GD) is the most common cause of hyperthyroidism. Maximal 30% of pediatric GD patients achieve remission with antithyroid drugs. The majority of patients therefore require definitive treatment. Both thyroidectomy and radioactive iodine (RAI) are often used as definitive treatment for GD. However, data on efficacy and short- and long-term side effects of RAI treatment for pediatric GD are relatively scarce.
methodsA systematic review of the literature (PubMed and Embase) was performed to identify studies reporting the efficacy or short- and long-term side effects of RAI treatment in pediatric GD.
resultsTwenty-three studies evaluating 1,283 children and adolescents treated with RAI for GD were included. The treatment goal of RAI treatment changed over time, from trying to achieve euthyroidism in the past to aiming at complete thyroid destruction and subsequent hypothyroidism in the last 3 decades. The reported efficacy of a first RAI treatment when aiming at hypothyroidism ranged from 42.8 to 97.5%, depending on the activity administered. The efficacy seems to increase with higher RAI activities. When aiming at hypothyroidism, both short- and long-term side effects of treatment are very rare. Long-term side effects were mainly seen in patients in whom treatment aimed at achieving euthyroidism.
conclusionRAI is a safe definitive treatment option for pediatric GD when aiming at complete thyroid destruction. When aiming at hypothyroidism, the efficacy of treatment seems to increase with a higher RAI activity. Prospective studies are needed to determine the optimal RAI dosing regimen in pediatric GD.
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