Evidence map›Paper›PMID 34540699›Full record

ArticleFrontiers in oncology2021

Design, Synthesis, and Biological Evaluation of Benzo[cd]indol-2(1H)-ones Derivatives as a Lysosome-Targeted Anti-metastatic Agent.

Jinghua Li, Shuai Chen, Yancong Zhao, Huiyuan Gong, Tong Wang, Xiaoling Ge, Yuxia Wang, Chenguang Zhu, Liang Chen, Fujun Dai and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Jinghua LiKey Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China.
Shuai ChenKey Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China.
Yancong ZhaoThe First Affiliated Hospital, Henan University, Kaifeng, China.
Huiyuan GongKey Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China.
Tong WangInstitute of Chemical Biology, School of Pharmacy, Henan University, Kaifeng, China.
Xiaoling GeCollege of Chemistry and Chemical Engineering Henan University, Kaifeng, China.
Yuxia WangCollege of Chemistry and Chemical Engineering Henan University, Kaifeng, China.
Chenguang ZhuKey Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China.
Liang ChenKey Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China.
Fujun DaiKey Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China.
Songqiang XieInstitute of Chemical Biology, School of Pharmacy, Henan University, Kaifeng, China.
Chaojie WangKey Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China.
Wen LuoKey Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China.
Henan University · CNFirst Affiliated Hospital of Henan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysosomes have become a hot topic in tumor therapy; targeting the lysosome is therefore a promising strategy in cancer therapy. Based on our previous lysosome-targeted bio-imaging agent, homospermine-benzo[cd]indol-2(1H)-one conjugate (HBC), we further developed three novel series of polyamine- benzo[cd]indol-2(1H)-one conjugates. Among them, compound 15f showed potent inhibitory activity in hepatocellular carcinoma migration both

Indexed as

apoptosisautophagybenzo[cd]indol-2(1H)-ones derivativesmetastasispolyamine

Identifiers

PMID34540699
PMCPMC8446683
OpenAlexW3198585795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.