Evidence map›Paper›PMID 34540672›Full record

ReviewFrontiers in oncology2021

Immunotherapy in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck.

Ronan W Hsieh, Steven Borson, Anastasia Tsagianni, Dan P Zandberg

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06163534 (TEMPUS PHOENIX HNSCC STUDY), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06163534 recruitingnot on this mapstarted 2024, after this paper: background citation

TEMPUS PHOENIX HNSCC STUDY: A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

Typeobservational_patient_registrySponsorTempus AIRan2024 to 2028Enrolled500ConditionsHead and Neck Squamous Cell Carcinoma
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Preexisting TCR Clones Drive Major Pathologic Responses in Patients with HNSCC Treated with Dual Immune Checkpoint Inhibitors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ronan W HsiehDivision of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, United States.
Steven BorsonDivision of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, United States.
Anastasia TsagianniDivision of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, United States.
Dan P ZandbergDivision of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, United States.
UPMC Hillman Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck cancer is the 6

Indexed as

head and neck cancerHNSCCimmunotherapymetastaticPD-1PD-L1recurrentsystemic therapy

Identifiers

PMID34540672
PMCPMC8440813
OpenAlexW3196817178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.