Evidence map›Paper›PMID 34540622›Full record

ArticleInternational journal of ophthalmology2021

Association between cystatin C and diabetic retinopathy among type 2 diabetic patients in China: a Meta-analysis.

Nan Yang, Yun-Fei Lu, Xiao Yang, Kui Jiang, Ai-Min Sang, Hui-Qun Wu

Abstract read
In one paragraph

Article in International journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. The Mechanisms of Inflammatory Factors and the Total Load of Cerebral Small Vessel Disease in Diabetic Retinopathy and Cognitive Impairment.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nan YangDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China.
Yun-Fei LuDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China.
Xiao YangDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China.
Kui JiangDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China.
Ai-Min SangDepartment of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
Hui-Qun WuDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo explore the correlation between cystatin C (Cys-C) and diabetic retinopathy (DR) in those patients with type 2 diabetes mellitus (DM) in China.

methodsArticles were collected from China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, EMBASE, Cochrane Library, Clinical Trials.gov, and Google Scholar. Quality and risk of bias within included studies was assessed using the Newcastle-Ottawa scale (NOS). Heterogeneity was determined by using Cochran's

resultsCys-C level in DR patients was increased compared with that of DWR (total MD: 0.69, 95%CI: 0.41 to 0.97,

conclusionThe elevated Cys-C is closely related with DR and probably plays a critical role in its progression.

Indexed as

cystatin Cdiabetic retinopathyMeta-analysis

Identifiers

PMID34540622
PMCPMC8403854

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.