ArticleAmerican journal of translational research2021
Study on the value of molecular biology combined with liquid MGIT culture method in clinical examination of mycobacterium tuberculosis.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the clinical value of molecular biology (xpert MTB/RIF) combined with a liquid mycobacterium culture tube (MGIT) in the clinical examination of Mycobacterium tuberculosis (MTB).
methodsA total of 782 patients with suspected pulmonary tuberculosis who came to our hospital from February 2018 to February 2020 were selected as the research subjects. Sputum samples of all patients were taken in the morning, and BACTEC MGIT culture and xpert MTB/RIF, Lowenstein-Jenden (L-J) culture and acid fast staining microscopy were used respectively to detect the sputum samples. The positive samples were cultured, and the bacteria identification and liquid drug sensitivity test were carried out. We also analyzed the value of xpert MTB/RIF combined with MGIT culture method in the clinical testing of MTB.
results(1) Among the 782 suspected patients, 405 cases were diagnosed with pulmonary tuberculosis and 377 cases were non tuberculosis patients. The sensitivity of smear microscopy was 17.28% (70/405), the specificity was 98.94% (373/377), and the average time was 3.05 h. The sensitivity of L-J culture test was 20.49% (83/405), the specificity was 97.61% (368/377), and the average time was 28.58 h. The sensitivity of MGIT culture test was 38.02% (154/405), the specificity was 96.82% (365/377), and the average time was 11.23 h. The sensitivity of xpert MTB/RIF test was 36.54% (148/405), the specificity was 99.46% (375/377), and the average time was 2.03 h. The sensitivity of MTB/RIF + MGIT test was 42.47% (172/405), the specificity was 96.02% (362/377), and the average time was 11.29 h. The sensitivity of MTB/RIF combined with MGIT culture was significantly higher than that of smear microscopy and L-J culture (χ
conclusionThe method of molecular biology combined with MGIT has a high sensitivity and specificity for clinical diagnosis of MTB.
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34540106PMC8430174W3199518420What OpenQuestion holds
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